Human Acyl-CoA : Cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis
文献类型：期刊论文
| 作者 | Chang, C; Dong, RH; Miyazaki, A; Sadashita, N; Zhang, Y; Liu, J; Guo, M; Li, BL; Chang, TY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2006 |
| 卷号 | 38期号:3页码:151-156 |
| 关键词 | acyl-CoA cholesterol acyltransferase cholesterol cholesteryl ester atherosclerosis |
| 通讯作者 | Chang, C (reprint author), Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA.,Catherine.Chang@dartmouth.edu |
| 英文摘要 | Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. At the single-cell level, ACAT serves as a regulator of intracellular cholesterol homeostasis. In addition, ACAT supplies cholesteryl esters for lipoprotein assembly in the liver and small intestine. Under pathological conditions, the accumulation of cholesteryl esters produced by ACAT in macrophages contributes to foam cell formation, a hallmark of the early stage of atherosclerosis. Several reviews addressing various aspects of ACAT and ACAT inhibitors are available [1-8]. This review briefly outlines the current knowledge on the biochemical properties of human ACATs, and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventions against atherosclerosis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | MONOCYTE-DERIVED MACROPHAGES ; HAMSTER OVARY CELLS ; COENZYME-A ; IN-VITRO ; DENSITY-LIPOPROTEIN ; HUMAN LIVER ; EXPRESSION ; MICE ; INHIBITORS ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235937800001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1683]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chang, C,Dong, RH,Miyazaki, A,et al. Human Acyl-CoA : Cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2006,38(3):151-156. |
| APA | Chang, C.,Dong, RH.,Miyazaki, A.,Sadashita, N.,Zhang, Y.,...&Chang, TY.(2006).Human Acyl-CoA : Cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,38(3),151-156. |
| MLA | Chang, C,et al."Human Acyl-CoA : Cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 38.3(2006):151-156. |
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