SNAP-25 in hippocampal CA3 region is required for long-term memory formation
文献类型：期刊论文
| 作者 | Hou, QL; Gao, X; Lu, Q; Zhang, XH; Tu, YY; Jin, ML; Zhao, GP; Yu, L; Jing, NH; Li, BM |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 347期号:4页码:955-962 |
| 关键词 | SNAP-25 hippocampus memory long-term potentiation rat |
| 通讯作者 | Li, BM (reprint author), Fudan Univ, Inst Brain Sci, Lab Higher Brain Funct, 220 Han Dan Rd, Shanghai 200433, Peoples R China.,bmli@fudan.edu.cn |
| 英文摘要 | SNAP-25 is a synaptosomal protein of 25 kDa, a key component of synaptic vesicle-docking/fusion machinery, and plays a critical role in exocytosis and neurotransmitter release. We previously reported that SNAP-25 in the hippocampal CA1 region is involved in consolidation of contextual fear memory and water-maze spatial memory (Hou et al. European J Neuroscience, 20: 1593-1603, 2004). SNAP-25 is expressed not only in the CA1 region, but also in the CA3 region, and the SNAP-25 mRNA level in the CA3 region is higher than in the CA1 region. Here, we provide evidence that SNAP-25 in the CA3 region is also involved in learning/memory. Intra-CA3 infusion of SNAP-25 antisense oligonucleotide impaired both long-term contextual fear memory and water-maze spatial memory, with short-term memory intact. Furthermore, the SNAP-25 antisense oligonucleotide suppressed the long-term potentiation (LTP) of field excitatory post-synaptic potential (FEPSP) in the mossy-fiber pathway (DG-CA3 pathway), with no effect on paired-pulse facilitation of the fEPSP. These results are consistent with the notion that SNAP-25 in the hippocampal CA3 region is required for long-term memory formation. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SYNAPTOSOMAL-ASSOCIATED PROTEIN ; NMDA RECEPTOR TRAFFICKING ; KAINIC ACID ; MEDIATED DISRUPTION ; PYRAMIDAL CELLS ; SPATIAL MEMORY ; AXONAL GROWTH ; CA2+ CHANNELS ; RAT-BRAIN ; POTENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239681100016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1698]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hou, QL,Gao, X,Lu, Q,et al. SNAP-25 in hippocampal CA3 region is required for long-term memory formation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,347(4):955-962. |
| APA | Hou, QL.,Gao, X.,Lu, Q.,Zhang, XH.,Tu, YY.,...&Li, BM.(2006).SNAP-25 in hippocampal CA3 region is required for long-term memory formation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,347(4),955-962. |
| MLA | Hou, QL,et al."SNAP-25 in hippocampal CA3 region is required for long-term memory formation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347.4(2006):955-962. |
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