A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis
文献类型：期刊论文
| 作者 | Teng, XK; Yang, J; Xie, Y; Ni, ZM; Hu, RY; Shi, L; Lin, ZX; Hu, LD; Zhao, GP; Ding, XY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 342期号:4页码:1223-1227 |
| 关键词 | urokinase receptor spermatogenesis testis scleroderma peripheral leukocytes |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200233, Peoples R China.,xyding@sunm.shcnc.ac.cn ; xykoiig@srcb.ac.cn |
| 英文摘要 | The urokinase receptor, uPAR, which binds to the Urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of it contraceptive vaccine. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | UROKINASE PLASMINOGEN-ACTIVATOR ; SERTOLI CELLS ; RECEPTOR ; LOCALIZATION ; SURFACE ; ADHESION ; CLONING ; TRACT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236316100032 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1701]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Teng, XK,Yang, J,Xie, Y,et al. A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,342(4):1223-1227. |
| APA | Teng, XK.,Yang, J.,Xie, Y.,Ni, ZM.,Hu, RY.,...&Kong, XY.(2006).A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,342(4),1223-1227. |
| MLA | Teng, XK,et al."A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 342.4(2006):1223-1227. |
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