Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2
文献类型：期刊论文
| 作者 | Jin, CY; Kato, K; Chimura, T; Yamasaki, T; Nakade, K; Murata, T; Li, HJ; Pan, JZ; Zhao, MJ; Sun, KL |
| 刊名 | NATURE STRUCTURAL & MOLECULAR BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 13期号:4页码:331-338 |
| 通讯作者 | Yokoyama, KK (reprint author), Natl Inst Diabet & Digest & Kidney Dis, Lab Mol Biol, US Natl Inst Hlth, Bethesda, MD 20892 USA.,kazu@brc.riken.jp |
| 英文摘要 | Jun dimerization protein-2 ( JDP2) is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Here, we examine the functional mechanisms of JDP2 and show that it can inhibit p300-mediated acetylation of core histones in vitro and in vivo. Inhibition of histone acetylation requires the N-terminal 35 residues and the DNA-binding region of JDP2. In addition, we demonstrate that JDP2 has histone-chaperone activity in vitro. These results suggest that the sequence-specific DNA-binding protein JDP2 may control transcription via direct regulation of the modification of histones and the assembly of chromatin. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | JUN DIMERIZATION PROTEIN-2 ; ACETYLTRANSFERASE ACTIVITY ; RETINOIC ACID ; ONCOPROTEIN E1A ; AP-1 REPRESSOR ; F9 CELLS ; CHROMATIN ; DIFFERENTIATION ; DNA ; PHOSPHORYLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236581400014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1707]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jin, CY,Kato, K,Chimura, T,et al. Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2006,13(4):331-338. |
| APA | Jin, CY.,Kato, K.,Chimura, T.,Yamasaki, T.,Nakade, K.,...&Yokoyama, KK.(2006).Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2.NATURE STRUCTURAL & MOLECULAR BIOLOGY,13(4),331-338. |
| MLA | Jin, CY,et al."Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2".NATURE STRUCTURAL & MOLECULAR BIOLOGY 13.4(2006):331-338. |
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