Two novel O-superfamily conotoxins from Conus vexillum
文献类型：期刊论文
| 作者 | Jiang, H; Xu, CQ; Wang, CZ; Fan, CX; Zhao, TY; Chen, JS; Chi, CW |
| 刊名 | TOXICON
 |
| 出版日期 | 2006 |
| 卷号 | 47期号:4页码:425-436 |
| 关键词 | cone snails Conus vexillum O-superfamily conotoxin bioassay cDNA cloning |
| 通讯作者 | Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China.,chi@sunm.shcnc.ac.cn |
| 英文摘要 | O-superfamily conotoxins include several families that have diverse pharmacological activity on Na+, K+ or Ca2+ channels. These superfamily toxins have been mainly found in fish-hunting and mollusk-hunting Conus species. Here, we reported two novel O-superfamily conotoxins, vx6a and vx6b, purified from a worm-hunting cone snail, Conus vexillum. Though their cysteine framework and signal peptides share high similarity with those of other members of O-superfamily, the mature vx6a and vx6b both have a low sequence homology with others. To test the biological function of vx6a, the toxin was chemically synthesized and then tested on the locust. dorsal unpaired median (DUM) neuron system which containing various ion channels. Although no any activity on ion channels was found on the DUM neuron system, vx6a Could clearly elicit a series of symptoms in mouse via intracranial injection, Such as quivering, climbing, scratching, barrel rolling and paralysis of limbs at different dose. (c) 2005 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | BUTHUS-MARTENSI KARSCH ; CALCIUM-CHANNEL SUBTYPES ; OMEGA-CONOTOXIN ; VENOM PEPTIDES ; SEQUENCE ALIGNMENT ; MARINE SNAIL ; K+ CHANNEL ; TOXIN ; CLONING ; PURIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236534700007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1712]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, H,Xu, CQ,Wang, CZ,et al. Two novel O-superfamily conotoxins from Conus vexillum[J]. TOXICON,2006,47(4):425-436. |
| APA | Jiang, H.,Xu, CQ.,Wang, CZ.,Fan, CX.,Zhao, TY.,...&Chi, CW.(2006).Two novel O-superfamily conotoxins from Conus vexillum.TOXICON,47(4),425-436. |
| MLA | Jiang, H,et al."Two novel O-superfamily conotoxins from Conus vexillum".TOXICON 47.4(2006):425-436. |
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