The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning
文献类型：期刊论文
| 作者 | Wang, XM; Gao, X; Zhang, XH; Tu, YY; Jin, ML; Zhao, GP; Yu, L; Jing, NH; Li, BM |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 340期号:4页码:1023-1027 |
| 关键词 | motor skill learning cerebellum Tob rat |
| 通讯作者 | Li, BM (reprint author), Fudan Univ, Inst Neurobiol, Lab Higher Brain Funct, 220 Han Dan Rd, Shanghai 200433, Peoples R China.,bmli@fudan.edu.cn |
| 英文摘要 | Tob (transducer of ErbB-2) is a negative cell cycle regulator with anti-proliferative activity in peripheral tissues. Our previous study identified Tob as a protein involved in hippocampus-dependent memory consolidation (M.L. Jin, X.M. Wang, Y.Y. Tu, X.H. Zhang, X. Gao, N. Guo, Z.Q. Xie G.P. Zhao, N.H. Jing, B.M. Li, Y.Yu, The negative cell cycle regulator, Tob (Transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory, Neuroscience 131 (2005) 647-659). Here, we provide evidence that Tob in the central nervous System is engaged in acquisition of motor skill. Tob has a relatively high expression in the cerebellum. Tob expression is up-regulated in the cerebellum after rats receive training on a rotarod-running task. Rats infused with Tob antisense oligonucleotides into the 4th ventricle exhibit a severe deficit in running on a rotating rod or walking across a horizontally elevated beam. (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | LURCHER MUTANT MICE ; MEMORY ; ORGANIZATION ; CEREBELLUM ; PROTEIN ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235041500002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1714]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XM,Gao, X,Zhang, XH,et al. The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,340(4):1023-1027. |
| APA | Wang, XM.,Gao, X.,Zhang, XH.,Tu, YY.,Jin, ML.,...&Li, BM.(2006).The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,340(4),1023-1027. |
| MLA | Wang, XM,et al."The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 340.4(2006):1023-1027. |
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