The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking
文献类型：期刊论文
| 作者 | Li, HT; Lin, XJ; Xie, YY; Hu, HY |
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2006 |
| 卷号 | 13期号:4页码:385-390 |
| 关键词 | alpha-synuclein oligomerization PICUP dimmer trimer |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | Assembly of a-synuclein (alpha-Syn) into neurotoxic oligomers and fibrils is an important pathogenic feature of Parkinson's disease. Studying the early events of alpha-Syn aggregation, such as oligomerization and nucleation, is indispensable to understanding the complicated process. Here, photo-induced cross-linking of unmodified proteins (PICUP) technique is applied to elucidate the early-stage oligomerization of alpha-Syn. Results show that alpha-Syn in solution exhibits a mixture of various species, including at least monomers, dimers and trimers. Aggregation of alpha-Syn probably originates from the dimeric and trimeric seeds. Furthermore, the N-terminal amphipathic region is proposed to be required for the oligomerization (dimerization and trimerization) process. This observation may extend our knowledge on the early events of alpha-Syn aggregation and the neurotoxic aggregation species. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | BETA-PROTEIN OLIGOMERIZATION ; PARKINSONS-DISEASE ; NEURODEGENERATION ; FIBRILLIZATION ; AGGREGATION ; ELUCIDATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237306400011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1716]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, HT,Lin, XJ,Xie, YY,et al. The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking[J]. PROTEIN AND PEPTIDE LETTERS,2006,13(4):385-390. |
| APA | Li, HT,Lin, XJ,Xie, YY,&Hu, HY.(2006).The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking.PROTEIN AND PEPTIDE LETTERS,13(4),385-390. |
| MLA | Li, HT,et al."The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking".PROTEIN AND PEPTIDE LETTERS 13.4(2006):385-390. |
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