Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice
文献类型：期刊论文
| 作者 | Su, CQ; Peng, LH; Sham, J; Wang, XH; Zhang, Q; Chua, D; Liu, C; Cui, ZF; Xue, HB; Wu, HP |
| 刊名 | MOLECULAR THERAPY
 |
| 出版日期 | 2006 |
| 卷号 | 13期号:5页码:918-927 |
| 关键词 | human TERT promoter oncolytic adenovirus immune gene therapy virotherapy hepatocarcinoma model |
| 通讯作者 | Qian, QJ (reprint author), Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Lab Viral & Gene Therapy, Shanghai 200438, Peoples R China.,qianqj@sino-gene.cn |
| 英文摘要 | Among numerous gene therapeutic strategies for cancer treatment, gene transfer by conditionally replicative adenovirus (CRAd) of interferon-gamma (IFN-gamma) may be useful because of the possibility that it will yield IFN-gamma-mediated antiangiogenesis, immune responses, and CRAd-mediated oncolysis. In this study, we constructed a human TERT promoter-mediated oncolytic adenovirus targeting telomerase-positive cancers and armed with a mouse or human IFN-gamma gene to generate novel immune gene-viral therapeutic systems, CNHK300-miFN-gamma and CNHK300-hIFN-gamma, respectively. The systems can specifically target, replicate in, and lyse cancer cells, while sparing normal cells. The advantage of these systems is that the number of transgene copies and their expression increase markedly via viral replication within infected cancer cells, and replicated viral progeny can then infect additional cancer cells within the tumor mass. CNHK300-miFN-gamma induced regression of xenografts in liver cancer models in both immunodeficient and immunocompetent mice by triplex mechanisms including selective oncolysis, antiangiogenesis, and immune responses. We conclude that combining immune gene therapy and oncolytic virotherapy can enhance antitumor efficacy as a result of synergism between CRAd oncolysis and transgene composite antitumor responses. |
| 学科主题 | Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 关键词[WOS] | REPLICATIVE ADENOVIRUS ; IFN-GAMMA ; HEPATOCELLULAR-CARCINOMA ; CANCER-THERAPY ; EXPRESSION ; CELLS ; REGRESSION ; TUMORS ; HEPATOCARCINOMA ; IMMUNOTHERAPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237523000014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1719]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Su, CQ,Peng, LH,Sham, J,et al. Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice[J]. MOLECULAR THERAPY,2006,13(5):918-927. |
| APA | Su, CQ.,Peng, LH.,Sham, J.,Wang, XH.,Zhang, Q.,...&Qian, QJ.(2006).Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice.MOLECULAR THERAPY,13(5),918-927. |
| MLA | Su, CQ,et al."Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice".MOLECULAR THERAPY 13.5(2006):918-927. |
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