Reserpine-induced model of stress suppresses mucosal immunity
文献类型：期刊论文
| 作者 | Bao, S; Fei, J; Shen, J; Gong, SJ; Fang, H; Husband, AJ |
| 刊名 | IMMUNOLOGY AND CELL BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 84期号:6页码:537-542 |
| 关键词 | humoral immunity intestine mucosa stress/depression |
| 通讯作者 | Bao, S (reprint author), Univ Sydney, Fac Med, Dept Pathol, Discipline Pathol, Sydney, NSW 2006, Australia.,bobbao@med.usyd.edu.au |
| 英文摘要 | Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/depression-induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine-treated group. No significant difference of CD4(+), CD8(+) or Mac1(+) cells between reserpine-treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated. |
| 学科主题 | Cell Biology ; Immunology |
| 类目[WOS] | Cell Biology ; Immunology |
| 关键词[WOS] | SYMPATHETIC INNERVATION ; IN-VIVO ; RESPONSES ; GAMMA ; MICE ; RAT ; INTERLEUKIN-6 ; PARAGANGLIA ; ANTIBODIES ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241624800006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1724]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Bao, S,Fei, J,Shen, J,et al. Reserpine-induced model of stress suppresses mucosal immunity[J]. IMMUNOLOGY AND CELL BIOLOGY,2006,84(6):537-542. |
| APA | Bao, S,Fei, J,Shen, J,Gong, SJ,Fang, H,&Husband, AJ.(2006).Reserpine-induced model of stress suppresses mucosal immunity.IMMUNOLOGY AND CELL BIOLOGY,84(6),537-542. |
| MLA | Bao, S,et al."Reserpine-induced model of stress suppresses mucosal immunity".IMMUNOLOGY AND CELL BIOLOGY 84.6(2006):537-542. |
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