中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia

文献类型:期刊论文

作者He, L; Zhou, G; He, YL; Xie, LK; Xiong, J; Lei, H; Wei, L; Hu, CS; Liu, JY; Jiang, MS
刊名JOURNAL OF IMMUNOLOGY
出版日期2006
卷号177期号:6页码:3644-3656
通讯作者Tan, JQ (reprint author), Wuhan Univ, Sch Med, Dept Immunol, Dong Hu Rd 115, Wuhan 430071, Peoples R China.,jinquan_tan@hotmail.com
英文摘要What mechanism that determines microglia accomplishing destructive or constructive role in CNS remains nebulous. We report here that intracranial priming and rechallenging with Toxoplasma gondii in mice elicit neurotoxic CCR9(+)Irg1(+) (immunoresponsive gene 1) microglia, which render resistance to apoptosis and produce a high level of TNF-alpha; priming and rechallenging with lymphocytic choriomeningitis virus elicit neurosupportive CXCR3(+)Irg1(-) microglia, which are sensitive to apoptosis and produce a high level of IL-10 and TGF-beta. Administration of CCR9 and/or Irg1 small interfering RNA alters the frequency and functional profiles of neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) microglia in vivo. Moreover, by using a series of different neurotropic pathogens, including intracellular parasites, chronic virus, bacteria, toxic substances, and CNS injury to intracranially prime and subsequent rechallenge mice, the bi-directional elicitation of microglia has been confirmed as neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) cells in these mouse models. These data suggest that there exist two different types of microglia, providing with a novel insight into microglial involvement in neurodegenerative and neuroinflammatory pathogenesis such as Alzheimer's disease and AIDS dementia.
学科主题Immunology
类目[WOS]Immunology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; T-CELLS ; DISEASE PATHOGENESIS ; ACTIVATED MICROGLIA ; PERIVASCULAR CELLS ; IMMUNE-RESPONSES ; VIRAL-INFECTION ; BRAIN MICROGLIA ; DENDRITIC CELLS ; CUTTING EDGE
收录类别SCI
语种英语
WOS记录号WOS:000240475300017
版本出版稿
源URL[http://202.127.25.143/handle/331003/1726]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
He, L,Zhou, G,He, YL,et al. Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia[J]. JOURNAL OF IMMUNOLOGY,2006,177(6):3644-3656.
APA He, L.,Zhou, G.,He, YL.,Xie, LK.,Xiong, J.,...&Tan, JQ.(2006).Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia.JOURNAL OF IMMUNOLOGY,177(6),3644-3656.
MLA He, L,et al."Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia".JOURNAL OF IMMUNOLOGY 177.6(2006):3644-3656.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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