Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia
文献类型：期刊论文
| 作者 | He, L; Zhou, G; He, YL; Xie, LK; Xiong, J; Lei, H; Wei, L; Hu, CS; Liu, JY; Jiang, MS |
| 刊名 | JOURNAL OF IMMUNOLOGY
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| 出版日期 | 2006 |
| 卷号 | 177期号:6页码:3644-3656 |
| 通讯作者 | Tan, JQ (reprint author), Wuhan Univ, Sch Med, Dept Immunol, Dong Hu Rd 115, Wuhan 430071, Peoples R China.,jinquan_tan@hotmail.com |
| 英文摘要 | What mechanism that determines microglia accomplishing destructive or constructive role in CNS remains nebulous. We report here that intracranial priming and rechallenging with Toxoplasma gondii in mice elicit neurotoxic CCR9(+)Irg1(+) (immunoresponsive gene 1) microglia, which render resistance to apoptosis and produce a high level of TNF-alpha; priming and rechallenging with lymphocytic choriomeningitis virus elicit neurosupportive CXCR3(+)Irg1(-) microglia, which are sensitive to apoptosis and produce a high level of IL-10 and TGF-beta. Administration of CCR9 and/or Irg1 small interfering RNA alters the frequency and functional profiles of neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) microglia in vivo. Moreover, by using a series of different neurotropic pathogens, including intracellular parasites, chronic virus, bacteria, toxic substances, and CNS injury to intracranially prime and subsequent rechallenge mice, the bi-directional elicitation of microglia has been confirmed as neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) cells in these mouse models. These data suggest that there exist two different types of microglia, providing with a novel insight into microglial involvement in neurodegenerative and neuroinflammatory pathogenesis such as Alzheimer's disease and AIDS dementia. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; T-CELLS ; DISEASE PATHOGENESIS ; ACTIVATED MICROGLIA ; PERIVASCULAR CELLS ; IMMUNE-RESPONSES ; VIRAL-INFECTION ; BRAIN MICROGLIA ; DENDRITIC CELLS ; CUTTING EDGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240475300017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1726]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | He, L,Zhou, G,He, YL,et al. Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia[J]. JOURNAL OF IMMUNOLOGY,2006,177(6):3644-3656. |
| APA | He, L.,Zhou, G.,He, YL.,Xie, LK.,Xiong, J.,...&Tan, JQ.(2006).Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia.JOURNAL OF IMMUNOLOGY,177(6),3644-3656. |
| MLA | He, L,et al."Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia".JOURNAL OF IMMUNOLOGY 177.6(2006):3644-3656. |
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