Systematic analysis of head-to-head gene organization: Evolutionary conservation and potential biological relevance
文献类型：期刊论文
| 作者 | Li, YY; Yu, H; Guo, ZM; Guo, TQ; Tu, K; Li, YX |
| 刊名 | PLOS COMPUTATIONAL BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 2期号:7页码:e74-e74 |
| 通讯作者 | Li, YX (reprint author), Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China.,yxli@scbit.org |
| 英文摘要 | Several "head-to-head'' (or "bidirectional'' )gene pairs have been studied in individual experiments, but genome-wide analysis of this gene organization, especially in terms of transcriptional correlation and functional association, is still insufficient. We conducted a systematic investigation of head-to-head gene organization focusing on structural features, evolutionary conservation, expression correlation and functional association. Of the present 1,262, 1,071, and 491 head-to-head pairs identified in human, mouse, and rat genomes, respectively, pairs with 1 - to 400 -base pair distance between transcription start sites form the majority (62.36%, 64.15%, and 55.19% for human, mouse, and rat, respectively) of each dataset, and the largest group is always the one with a transcription start site distance of 101 to 200 base pairs. The phylogenetic analysis among Fugu, chicken, and human indicates a negative selection on the separation of head-to-head genes across vertebrate evolution, and thus the ancestral existence of this gene organization. The expression analysis shows that most of the human head-to-head genes are significantly correlated, and the correlation could be positive, negative, or alternative depending on the experimental conditions. Finally, head-to-head genes statistically tend to perform similar functions, and gene pairs associated with the significant cofunctions seem to have stronger expression correlations. The findings indicate that the head- to-head gene organization is ancient and conserved, which subjects functionally related genes to correlated transcriptional regulation and thus provides an exquisite mechanism of transcriptional regulation based on gene organization. These results have significantly expanded the knowledge about head- to-head gene organization. Supplementary materials for this study are available at http://www.scbit.org/h2h. |
| 学科主题 | Biochemistry & Molecular Biology; Mathematical & Computational Biology |
| 类目[WOS] | Biochemical Research Methods ; Mathematical & Computational Biology |
| 关键词[WOS] | BIDIRECTIONAL PROMOTER ; HUMAN GENOME ; MOUSE ; EXPRESSION ; ANTISENSE ; ALPHA-1(IV) ; TRANSCRIPTS ; DISCOVERY ; SEQUENCE ; ELEMENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239494100004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1736]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, YY,Yu, H,Guo, ZM,et al. Systematic analysis of head-to-head gene organization: Evolutionary conservation and potential biological relevance[J]. PLOS COMPUTATIONAL BIOLOGY,2006,2(7):e74-e74. |
| APA | Li, YY,Yu, H,Guo, ZM,Guo, TQ,Tu, K,&Li, YX.(2006).Systematic analysis of head-to-head gene organization: Evolutionary conservation and potential biological relevance.PLOS COMPUTATIONAL BIOLOGY,2(7),e74-e74. |
| MLA | Li, YY,et al."Systematic analysis of head-to-head gene organization: Evolutionary conservation and potential biological relevance".PLOS COMPUTATIONAL BIOLOGY 2.7(2006):e74-e74. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。