Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts
文献类型：期刊论文
| 作者 | Chen, Y; Du, Z; Yao, Z |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:7页码:641-650 |
| 关键词 | Nanog F9 embryonal carcinoma cells endoderm differentiation |
| 通讯作者 | Chen, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Biochem & Cell Biol,Lab Mol & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,chenym@sibs.ac.cn |
| 英文摘要 | Nanog is a recently discovered homeodomain transcription factor that sustains the pluripotency of embryonic stem (ES) cells and blocks their differentiation into endoderm. The murine F9 embryonal carcinoma cell line is a well-documented model system for endoderm cell lineage differentiation. Here, we examined the function of Nanog in F9 cell endoderm differentiation. Over-expression of Nanog returns the F9 cells to the early status of ES cells and represses the differentiation of primitive endoderm and parietal endoderm in F9 cells, whereas it has no effect on the differentiation of visceral endoderm. In contrast, the expression of C-terminal domain-truncated Nanog spontaneously promotes endoderm differentiation in F9 cells. These data suggest that Nanog is required to sustain the proper undifferentiated status of F9 cells, and the C-terminal domain of Nanog transduces the most effects in repressing primitive endoderm and parietal endoderm differentiation in F9 cells. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | PLURIPOTENCY SUSTAINING FACTOR ; TERATOCARCINOMA STEM-CELLS ; PARIETAL ENDODERM ; RETINOIC ACID ; MOUSE EMBRYOS ; SELF-RENEWAL ; ES CELLS ; EXPRESSION ; GENE ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239750600005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1739]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Y,Du, Z,Yao, Z. Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts[J]. CELL RESEARCH,2006,16(7):641-650. |
| APA | Chen, Y,Du, Z,&Yao, Z.(2006).Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.CELL RESEARCH,16(7),641-650. |
| MLA | Chen, Y,et al."Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts".CELL RESEARCH 16.7(2006):641-650. |
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