Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation
文献类型：期刊论文
| 作者 | Wang, C; Xia, CH; Bian, W; Liu, L; Lin, W; Chen, YG; Ang, SL; Jing, NH |
| 刊名 | MOLECULAR BIOLOGY OF THE CELL
 |
| 出版日期 | 2006 |
| 卷号 | 17期号:7页码:3075-3084 |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn |
| 英文摘要 | FGF8, a member of the fibroblast growth factor (FGF) family, has been shown to play important roles in different developing systems. Mouse embryonic carcinoma P19 cells could be induced by retinoic acid (RA) to differentiate into neuroectodermal cell lineages, and this process is cell aggregation dependent. In this report, we show that FGF8 expression is transiently up-regulated upon P19 cell aggregation, and the aggregation-dependent FGF8 elevation is pluripotent stem cell related. Overexpressing FGF8 promotes RA-induced monolayer P19 cell neural differentiation. Inhibition of FGF8 expression by RNA interference or blocking FGF signaling by the FGF receptor inhibitor, SU5402, attenuates neural differentiation of the P19 cell. Blocking the bone morphogenetic protein (BMP) pathway by overexpressing Smad6 in P19 cells, we also show that FGF signaling plays a BMP inhibition-independent role in P19 cell neural differentiation. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | EMBRYONAL CARCINOMA-CELLS ; NEURONAL DIFFERENTIATION ; STEM-CELLS ; VISCERAL-ENDODERM ; CHICK-EMBRYO ; TARGETED DISRUPTION ; BMP INHIBITION ; NESTIN GENE ; IN-VITRO ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238721000019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1741]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, C,Xia, CH,Bian, W,et al. Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation[J]. MOLECULAR BIOLOGY OF THE CELL,2006,17(7):3075-3084. |
| APA | Wang, C.,Xia, CH.,Bian, W.,Liu, L.,Lin, W.,...&Jing, NH.(2006).Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation.MOLECULAR BIOLOGY OF THE CELL,17(7),3075-3084. |
| MLA | Wang, C,et al."Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation".MOLECULAR BIOLOGY OF THE CELL 17.7(2006):3075-3084. |
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