Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy
文献类型：期刊论文
| 作者 | Tang, L; Li, HT; Du, HN; Zhang, F; Hu, XF; Hu, HY |
| 刊名 | MICRON
 |
| 出版日期 | 2006 |
| 卷号 | 37期号:7页码:675-679 |
| 关键词 | disassembly assembly alpha-synuclein in situ atomic force microscopy (AFM) Parkinson's disease |
| 通讯作者 | Tang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Baojia Rd, Shanghai 201800, Peoples R China.,tanglin@sinap.ac.cn |
| 英文摘要 | In this report, we applied in situ atomic force microscopy (AFM) to study the dynamic process of disassembly-assembly of alpha-synuclein (alpha-Syn) fibrils in different solutions. Most of the mica-adsorbed alpha-Syn fibrils disassemble into small particles step-by-step on the mica surface in diluted solutions, yet a few short fibrils still extend to form longer fibrils. This process usually started randomly at the center of the long fibrils, which progressively disassemble into short fragments and small protein particles of varying size. Compared to disassembly, assembly happened infrequently when the protein concentration was low. It was observed directly by AFM that the chaotropic agent guanidinium chloride rapidly breaks the long alpha-Syn fibrils. (c) 2006 Elsevier Ltd. All rights reserved. |
| 学科主题 | Microscopy |
| 类目[WOS] | Microscopy |
| 关键词[WOS] | PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; AMYLOID FIBRILS ; FIBRILLIZATION ; PATHOGENESIS ; MECHANISM ; FILAMENTS ; PEPTIDES ; VITRO |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240533000010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1746]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tang, L,Li, HT,Du, HN,et al. Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy[J]. MICRON,2006,37(7):675-679. |
| APA | Tang, L,Li, HT,Du, HN,Zhang, F,Hu, XF,&Hu, HY.(2006).Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy.MICRON,37(7),675-679. |
| MLA | Tang, L,et al."Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy".MICRON 37.7(2006):675-679. |
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