Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis
文献类型：期刊论文
| 作者 | Wang, Y; Wei, DM; Lai, Z; Le, YP |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 6期号:12页码:1825-1832 |
| 关键词 | triptolide chemokines adjuvant-induced arthritis |
| 通讯作者 | Wang, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Grad Sch, Shanghai 200031, Peoples R China.,yfwang@sibs.ac.cn |
| 英文摘要 | Triptolide, a diterpenoid triepoxide from Tripterygium wilfordii Hook F (TWHF), has been proven to have potent immunosuppressive and anti-inflammatory activities. It has been clinically used to treat patients with rheumatoid arthritis (RA), in which chemokines play an important role in immune and inflammatory responses. To investigate the effect of triptolide on MCP-1, MIP-1 alpha and RANTES, we used complete Freund's adjuvant to induce adjuvant-induced arthritis (AA) in rats. AA in rat is a useful experimental model of human RA. Our data show that the thickness of arthritic ankle decreases with administration of triptolide. Both mRNA and protein levels of MCP-1, MIP-1 alpha and RANTES in synovial tissue of rats with AA are significantly higher than those in normal rats. mRNA levels of MIP-1 alpha and RANTES increase in peripheral blood mononuclear cells of rats with AA in comparison with those in normal rats, whereas no MCP-1 mRNA can be detected. Triptolide can significantly inhibit rat AA induced over-expression of MCP-1, MIP-1 alpha and RANTES at both mRNA and protein levels in a dose-dependent manner. These results may contribute to the therapeutic effects of triptolide in rheumatoid arthritis. (c) 2006 Elsevier B.V. All rights reserved. |
| 学科主题 | Immunology; Pharmacology & Pharmacy |
| 类目[WOS] | Immunology ; Pharmacology & Pharmacy |
| 关键词[WOS] | WILFORDII HOOK-F ; COLLAGEN-INDUCED ARTHRITIS ; CHINESE HERBAL REMEDY ; MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; KAPPA-B ACTIVATION ; RHEUMATOID-ARTHRITIS ; GENE-EXPRESSION ; T-CELLS ; CYTOKINES ; SUPPRESSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000242063000008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1780]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Y,Wei, DM,Lai, Z,et al. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2006,6(12):1825-1832. |
| APA | Wang, Y,Wei, DM,Lai, Z,&Le, YP.(2006).Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis.INTERNATIONAL IMMUNOPHARMACOLOGY,6(12),1825-1832. |
| MLA | Wang, Y,et al."Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis".INTERNATIONAL IMMUNOPHARMACOLOGY 6.12(2006):1825-1832. |
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