Acceleration of alpha-synuclein aggregation by homologous peptides
文献类型：期刊论文
| 作者 | Du, HN; Li, HT; Zhang, F; Lin, XJ; Shi, JH; Shi, YH; Ji, LN; Hu, J; Lin, DH; Hu, HY |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2006 |
| 卷号 | 580期号:15页码:3657-3664 |
| 关键词 | alpha-synuclein GAV motif aggregation fibrillization homologous peptide Parkinson's disease |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Key Lab Prote, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | alpha-Synuclein (alpha-Syn), amyloid beta-protein and prion protein are among the amyloidogenic proteins that are associated with the neurodegenerative diseases. These three proteins share a homologous region with a consensus sequence mainly consisting of glycine, alanine and valine residues (accordingly named as the GAV motif), which was proposed to be the critical core for the fibrillization and cytotoxicity. To understand the role of the GAV motif in protein amyloidogenesis, we studied the effects of the homologous peptides corresponding to the sequence of GAV motif region (residues 66-74) on alpha-Syn aggregation. The result shows that these peptides can promote fibrillization of wild-type a-Syn and induce that of the charge-incorporated mutants but not the GAV-deficient alpha-Syn mutant. The acceleration of a-Syn aggregation by the homologous peptides is under a sequence-specific manner. The interplay between the GAV peptide and the core regions in alpha-Syn may accelerate the aggregation process and stabilize the fibrils. This finding provides clues for developing peptide mimics that could promote transforming the toxic oligomers or protofibrils into the inert mature fibrils. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | ABNORMAL PROTEIN AGGREGATION ; A-BETA COMPONENT ; ALZHEIMERS-DISEASE ; PARKINSONS-DISEASE ; PRION PROTEIN ; NEURODEGENERATIVE DISEASES ; AMYLOID FORMATION ; FIBRIL FORMATION ; LEWY BODIES ; SOLID-STATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238691600014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1787]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Du, HN,Li, HT,Zhang, F,et al. Acceleration of alpha-synuclein aggregation by homologous peptides[J]. FEBS LETTERS,2006,580(15):3657-3664. |
| APA | Du, HN.,Li, HT.,Zhang, F.,Lin, XJ.,Shi, JH.,...&Hu, HY.(2006).Acceleration of alpha-synuclein aggregation by homologous peptides.FEBS LETTERS,580(15),3657-3664. |
| MLA | Du, HN,et al."Acceleration of alpha-synuclein aggregation by homologous peptides".FEBS LETTERS 580.15(2006):3657-3664. |
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