Transforming growth factor-beta 1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism
文献类型：期刊论文
| 作者 | Yang, Y; Pan, X; Lei, W; Wang, J; Song, J |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2006 |
| 卷号 | 25期号:55页码:7235-7244 |
| 关键词 | PKD EMT cell cycle TGF-beta apoptosis signaling |
| 通讯作者 | Song, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | Apoptosis and epithelial-to-mesenchymal transition (EMT) have been implicated in a variety of biological processes, such as embryonic development, fibrosis and tumor progression. Transforming growth factor-beta (TGF-beta) can induce simultaneously both EMT and apoptotic response of epithelial cells. However, the underlying mechanism of these biological events remains not well understood. In the present study, we show that TGF-beta 1 induces apoptosis and EMT in AML-12 cells in a cell cycle-related manner, in which apoptosis and EMT took place at G2/M and G1/S phases, respectively. TGF-beta 1-induced apoptosis was correlated with different extent of caspase activation at different cell cycle phases. Interestingly, increased phosphorylation of protein kinase D (PKD) can be observed in G1/S phase in response to TGF-beta 1, and inhibition of PKD by inhibitor or by small interference RNA blocked EMT but not apoptosis. Our data suggest a previously unrecognized role of cell cycle state in the regulation of TGF-beta-induced EMT and apoptosis, and demonstrate that PKD is involved in the TGF-beta 1-induced EMT. |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 关键词[WOS] | PROTEIN-KINASE-D ; GROWTH-FACTOR-BETA ; CONFERS RESISTANCE ; TRANSDIFFERENTIATION ; ACTIVATION ; PLASTICITY ; MIGRATION ; P38 ; HEPATOCYTES ; PROGRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000242244700002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1810]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, Y,Pan, X,Lei, W,et al. Transforming growth factor-beta 1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism[J]. ONCOGENE,2006,25(55):7235-7244. |
| APA | Yang, Y,Pan, X,Lei, W,Wang, J,&Song, J.(2006).Transforming growth factor-beta 1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism.ONCOGENE,25(55),7235-7244. |
| MLA | Yang, Y,et al."Transforming growth factor-beta 1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism".ONCOGENE 25.55(2006):7235-7244. |
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