Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray
文献类型：期刊论文
| 作者 | Zhang, JS; Liu, Q; Li, YM; Hall, SH; French, FS; Zhang, YL |
| 刊名 | MOLECULAR AND CELLULAR ENDOCRINOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 250期号:1页码:169-177 |
| 关键词 | human epididymis microarray region-specific transcriptomes |
| 通讯作者 | Zhang, YL (reprint author), 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,ylzhang@sibs.ac.cn |
| 英文摘要 | Sperm maturation during passage through the epididymis depends on regionalized gene expression which maintains the progressively changing environment within the epididymal tubule. Towards defining the genes that drive the sequential maturation of spermatozoa, we profiled regionally regulated gene expression pattern in the epididymis of a fertile young male donor using Affymetrix human genome U133 plus 2.0 microarray representing approximately the whole human genome. Over 15 000 transcripts, almost one-third of the total on the array were identified in whole epididymis. Among them, 65% were detected in all three regions of the epididymis, 410 or 2.6% were present only in one region and the remaining 32.4% were distributed in two regions. Region-specific transcripts observed in caput (264), corpus (61) and cauda (81) epididymides were further classified as empirically determined reported genes or ESTs. This study revealed for the first time, the expression in human epididymis of a number of region-specific genes. The original data will be made publicly available on the Shanghai Science and Technology Database (http://www.scbit.org/human_epididymis_transcriptomes). (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Cell Biology; Endocrinology & Metabolism |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | FULL-LENGTH HUMAN ; BROWN-NORWAY RAT ; GENE-EXPRESSION ; SPERM MATURATION ; MOUSE EPIDIDYMIS ; PROTEIN ; CLONING ; LOCALIZATION ; ORCHIECTOMY ; SPERMATOZOA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238020900024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1814]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, JS,Liu, Q,Li, YM,et al. Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2006,250(1):169-177. |
| APA | Zhang, JS,Liu, Q,Li, YM,Hall, SH,French, FS,&Zhang, YL.(2006).Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray.MOLECULAR AND CELLULAR ENDOCRINOLOGY,250(1),169-177. |
| MLA | Zhang, JS,et al."Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray".MOLECULAR AND CELLULAR ENDOCRINOLOGY 250.1(2006):169-177. |
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