Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0
文献类型：期刊论文
| 作者 | Diao, LR; Zhang, BH; Xuan, CH; Sun, SG; Yang, K; Tang, YJ; Qiao, WT; Chen, QM; Geng, YQ; Wang, C |
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 308期号:1页码:196-210 |
| 关键词 | HSV-1 ICP0 AP-1 JNK TAK1 |
| 通讯作者 | Geng, YQ (reprint author), Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China.,yqgeng@public.tpt.tj.cn |
| 英文摘要 | The immediate early protein ICP0 encoded by herpes simplex virus I (HSV-1) is believed to activate transcription and consequently productive infection. The precise mechanisms of ICP0-mediated transactivation are under intensive study. Here, we demonstrate that ICP0 can strongly activate AP-1 responsive genes specifically. This activation is inhibited by c-Jun (S73A), c-Jun (S63/73A), TAK1 (K63W), but not by p38 (AF), ERK1 (K71R), ERK2 (K52R) and TRAF6 (C85A/H87A). We further investigate the relevancy of ERK, JNK and p38 MAPK pathways using their respective inhibitors PD98059, SP600125 and SB202190. Only SP600125 significantly attenuates the AP-1 responsive gene activation by ICP0. Consistent with these, the JNK is remarkably activated in response to ICP0, and this JNK activation is shown to be significantly attenuated by TAK1 (K63W). It turns out that ICP0 interacts specifically with TAK1 and stimulates its kinase activity. These findings reveal a new molecular mechanism ICP0 explores to regulate gene expression. (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Oncology ; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | HERPES-SIMPLEX-VIRUS ; TRANSCRIPTION FACTOR AP-1 ; EARLY GENE-EXPRESSION ; REGULATORY PROTEIN ; KAPPA-B ; CELL-PROLIFERATION ; LATENT INFECTION ; TYPE-1 ; INDUCTION ; PHOSPHORYLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230702300018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1840]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Diao, LR,Zhang, BH,Xuan, CH,et al. Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0[J]. EXPERIMENTAL CELL RESEARCH,2005,308(1):196-210. |
| APA | Diao, LR.,Zhang, BH.,Xuan, CH.,Sun, SG.,Yang, K.,...&Wang, C.(2005).Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0.EXPERIMENTAL CELL RESEARCH,308(1),196-210. |
| MLA | Diao, LR,et al."Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0".EXPERIMENTAL CELL RESEARCH 308.1(2005):196-210. |
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