Identification of a novel protein for memory regulation in the hippocampus
文献类型：期刊论文
| 作者 | Zhang, XH; Zhang, H; Tu, YY; Gao, X; Zhou, CF; Jin, ML; Zhao, GP; Jing, NH; Li, BM; Yu, L |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2005 |
| 卷号 | 334期号:2页码:418-424 |
| 关键词 | negative memory regulation hippyragranin spatial memory LTP antisense oligonucleotide |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci,Lab Mol Cell Biol, Inst Biochem & Cell Biol,Lab Stem Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,njing@sibs.ac.cen ; bmli@fudan.edu.cn ; lei.yu@uc.edu |
| 英文摘要 | Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation. (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; STORAGE ; PHOSPHATASE-1 ; CONSOLIDATION ; NEUROSCIENCE ; ENHANCEMENT ; CALCINEURIN ; INHIBITION ; GENES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230880200018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1856]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, XH,Zhang, H,Tu, YY,et al. Identification of a novel protein for memory regulation in the hippocampus[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,334(2):418-424. |
| APA | Zhang, XH.,Zhang, H.,Tu, YY.,Gao, X.,Zhou, CF.,...&Yu, L.(2005).Identification of a novel protein for memory regulation in the hippocampus.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,334(2),418-424. |
| MLA | Zhang, XH,et al."Identification of a novel protein for memory regulation in the hippocampus".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334.2(2005):418-424. |
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