Herpes virus proteins BICP0 and BICP0 can activate NF-kappa B by catalyzing I kappa B alpha ubiquitination
文献类型：期刊论文
| 作者 | Diao, LR; Zhang, BH; Fan, JK; Gao, X; Sun, SG; Yang, K; Dan, X; Jin, NH; Geng, YQ; Wang, C |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2005 |
| 卷号 | 17期号:2页码:217-229 |
| 关键词 | herpes virus ICP0 BICP0 ubiquitin I kappa B alpha |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol & Cellular Biol Lab, Box 49,320 Yue Yang Rd, Shanghai 200031, Peoples R China.,yqgeng@public.tpt.tj.cn |
| 英文摘要 | The immediate early proteins ICPO and BICPO from Herpes virus are promiscuous activators of both viral and cellular genes and play a critical role in virus life cycle. Here we report that ICPO and BICPO could induce NF-kappaB translocation from cytoplasm into nucleus and strongly activate NF-kappaB responsive genes specifically. This process was dependent on the RING domain of both proteins. In addition, ICPO interacted specifically with IkappaBalpha and its activating effect was attenuated by Ubch5A(C85A) and MG132, but not by IkappaBalpha(S32A/S36A). Remarkably, IkappaBalpha was poly-ubiquitinated by both ICPO and BICPO, in vitro and in vivo. These data indicate that ICPO and BICPO, functioning as ubiquitin ligases, are bona fide activators of NF-kappaB signaling pathway. Our study identifies a new way ICPO and BICPO explore to regulate gene expression. (C) 2004 Elsevier Inc. All rights reserved. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | HUMAN-IMMUNODEFICIENCY-VIRUS ; VIRUS-1-INFECTED CELL PROTEIN-0 ; SIMPLEX-VIRUS ; REGULATORY PROTEIN ; LATENT INFECTION ; ICP0 INTERACTS ; NUCLEAR DOMAIN ; TYPE-1 ; TRANSCRIPTION ; PML |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224930000009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1868]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Diao, LR,Zhang, BH,Fan, JK,et al. Herpes virus proteins BICP0 and BICP0 can activate NF-kappa B by catalyzing I kappa B alpha ubiquitination[J]. CELLULAR SIGNALLING,2005,17(2):217-229. |
| APA | Diao, LR.,Zhang, BH.,Fan, JK.,Gao, X.,Sun, SG.,...&Wang, C.(2005).Herpes virus proteins BICP0 and BICP0 can activate NF-kappa B by catalyzing I kappa B alpha ubiquitination.CELLULAR SIGNALLING,17(2),217-229. |
| MLA | Diao, LR,et al."Herpes virus proteins BICP0 and BICP0 can activate NF-kappa B by catalyzing I kappa B alpha ubiquitination".CELLULAR SIGNALLING 17.2(2005):217-229. |
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