PTEN - A novel anti-oncogenic function independent of phosphatase activity
文献类型：期刊论文
| 作者 | Okumura, K; Zhao, MJ; DePinho, RA; Furnari, FB; Cavenee, WK |
| 刊名 | CELL CYCLE
 |
| 出版日期 | 2005 |
| 卷号 | 4期号:4页码:540-542 |
| 关键词 | PTEN MSP58 C2 domain GLTSCR2/PICT1 PDZ FHA domain |
| 通讯作者 | Cavenee, WK (reprint author), Univ Calif San Diego, Ludwig Inst Canc Res, 9500 Gilman Dr, La Jolla, CA 92093 USA.,wcavenee@ucsd.edu |
| 英文摘要 | The PTEN gene is an important tumor suppressor mutated in a number of cancers. To date, its growth regulatory properties have been intimately linked to its ability to act as a protein and phosphoinositol phosphatase. Inactivation of the enzymatic activity of PTEN is primarily due to direct mutation of its amino-terminal catalytic domain but similar to 20% of mutations are in the carboxy-terminus, which regulates membrane localization, protein stability, cellular migration and p53 function. We identified a novel protein that interacts with this domain, the v-jun transcriptional target, MSP58. Binding of MSP58 to PTEN results in the suppression of MSP58-mediated transformation. However, this PTEN effect does not require its catalytic activity, suggesting additional mechanisms of PTEN action. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | TUMOR-SUPPRESSOR PTEN ; CELLULAR-TRANSFORMATION ; PROTEIN STABILITY ; GLIOMA-CELLS ; PHOSPHORYLATION ; DOMAIN ; MIGRATION ; MAGI-2 ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000229538600009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1897]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Okumura, K,Zhao, MJ,DePinho, RA,et al. PTEN - A novel anti-oncogenic function independent of phosphatase activity[J]. CELL CYCLE,2005,4(4):540-542. |
| APA | Okumura, K,Zhao, MJ,DePinho, RA,Furnari, FB,&Cavenee, WK.(2005).PTEN - A novel anti-oncogenic function independent of phosphatase activity.CELL CYCLE,4(4),540-542. |
| MLA | Okumura, K,et al."PTEN - A novel anti-oncogenic function independent of phosphatase activity".CELL CYCLE 4.4(2005):540-542. |
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