Suppression of morphine withdrawal syndrome by interleukin-2 and its gene
文献类型：期刊论文
| 作者 | Gu, JF; Yao, MZ; Wang, JH; Zhou, WH; Yang, GD; Liu, HF; Zhang, ZL; Liu, XY |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2005 |
| 卷号 | 16期号:4页码:387-391 |
| 关键词 | interleukin-2 interleukin-2 gene intrathecal injection morphine withdrawal syndrome |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could significantly decrease the number of jumps in mice. In rats, rIL-2 significantly suppressed irritating, diarrhea, weight loss, abnormal posture and salivation. Tendencies towards reductions in teeth chewing and dog-shaking were also observed. Furthermore, pcDNA3-IL-2 (8 mu g DNA) had a similar effect as 1 x 10(4) IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days. These findings provided further evidence for the neuroregulatory function of an immunological molecule such as IL-2. (c) 2005 Lippincott Williams T Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | INDUCED IMMUNOSUPPRESSION ; RAT ; RECEPTOR ; EXPRESSION ; BEHAVIOR ; MICE ; IL-2 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000227964300016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1902]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gu, JF,Yao, MZ,Wang, JH,et al. Suppression of morphine withdrawal syndrome by interleukin-2 and its gene[J]. NEUROREPORT,2005,16(4):387-391. |
| APA | Gu, JF.,Yao, MZ.,Wang, JH.,Zhou, WH.,Yang, GD.,...&Liu, XY.(2005).Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.NEUROREPORT,16(4),387-391. |
| MLA | Gu, JF,et al."Suppression of morphine withdrawal syndrome by interleukin-2 and its gene".NEUROREPORT 16.4(2005):387-391. |
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