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A nuclear function of beta-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription
文献类型：期刊论文
| 作者 | Kang, JH; Shi, YF; Xiang, B; Qu, B; Su, WJ; Zhu, M; Zhang, M; Bao, GB; Wang, FF; Zhang, XQ |
| 刊名 | CELL
 |
| 出版日期 | 2005 |
| 卷号 | 123期号:5页码:833-847 |
| 通讯作者 | Ma, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,lanma@fudan.edu.cn |
| 英文摘要 | Chromatin modification is considered to be a fundamental mechanism of regulating gene expression to generate coordinated responses to environmental changes, however, whether it could be directly regulated by signals mediated by G protein-coupled receptors (GPCRs), the largest surface receptor family, is not known. Here, we show that stimulation of delta-opioid receptor, a member of the GPCR family, induces nuclear translocation of beta-arrestin 1 (beta arr1), which was previously known as a cytosolic regulator and scaffold of GPCR signaling. In response to receptor activation, beta arr1 translocates to the nucleus and is selectively enriched at specific promoters such as that of p27 and c-fos, where it facilitates the recruitment of histone acetyltransferase p300, resulting in enhanced local histone H4 acetylation and transcription of these genes. Our results reveal a novel function of beta arr1 as a cytoplasm-nucleus messenger in GPCR signaling and elucidate an epigenetic mechanism for direct GPCR signaling from cell membrane to the nucleus through signal-dependent histone modification. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | PROTEIN-COUPLED RECEPTORS ; DELTA-OPIOID RECEPTORS ; BETA-ARRESTINS ; EXPORT SIGNAL ; MCM PROTEINS ; MICE LACKING ; CELL-CYCLE ; P38 MAPK ; C-FOS ; CHROMATIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000233814100017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1909]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Kang, JH,Shi, YF,Xiang, B,et al. A nuclear function of beta-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription[J]. CELL,2005,123(5):833-847. |
| APA | Kang, JH.,Shi, YF.,Xiang, B.,Qu, B.,Su, WJ.,...&Ma, L.(2005).A nuclear function of beta-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription.CELL,123(5),833-847. |
| MLA | Kang, JH,et al."A nuclear function of beta-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription".CELL 123.5(2005):833-847. |
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