RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour
文献类型：期刊论文
| 作者 | Wang, XD; Zhang, YQ; Kong, LW; Xie, ZQ; Lin, ZX; Guo, N; Strong, JA; Meij, JTA; Zhao, ZQ; Jing, NH |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 22期号:5页码:1090-1096 |
| 关键词 | allodynia chronic constriction injury of the sciatic nerve hyperalgesia neuropathic pain rat spinal cord |
| 通讯作者 | Zhao, ZQ (reprint author), Fudan Univ, Inst Neurobiol, 220 Han Dan Rd, Shanghai 200433, Peoples R China.,zqzhao@fudan.edu.cn ; njing@sibs.ac.cn ; lei.yu@uc.edu |
| 英文摘要 | Neuropathic pain from nerve injury by trauma, disease or surgery often causes prolonged suffering. To explore the molecular mechanisms that underlie neuropathic pain, we used mRNA from the L4-5 segments of the lumbar spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain, and differentially screened a cDNA library from the rat brain. A novel gene, termed RSEP1 (Rat Spinal cord Expression Protein 1), was identified. Northern blots revealed that RSEP1 was expressed mainly in the central nervous system including the cerebral cortex, hippocampus, brainstem and spinal cord, as well as in the kidney and ovary. In situ hybridization showed a high level of RSEP1 expression in the CA1, CA3 and dentate gyrus regions of the hippocampus and the small sensory neurons in the dorsal horn, as well as the large neurons in the ventral horn of the spinal cord. Intrathecal injection of RSEP1 antisense oligonucleotide into the spinal cord lumbar enlargement attenuated neuropathic pain behaviours in CCI rats, suggesting a functional involvement of RSEP1 in neuropathic pain. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | PERIPHERAL-NERVE INJURY ; RAT ; EXPRESSION ; ALLODYNIA ; PET ; REGION ; MEMORY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000231903000009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1910]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XD,Zhang, YQ,Kong, LW,et al. RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2005,22(5):1090-1096. |
| APA | Wang, XD.,Zhang, YQ.,Kong, LW.,Xie, ZQ.,Lin, ZX.,...&Yu, L.(2005).RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour.EUROPEAN JOURNAL OF NEUROSCIENCE,22(5),1090-1096. |
| MLA | Wang, XD,et al."RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour".EUROPEAN JOURNAL OF NEUROSCIENCE 22.5(2005):1090-1096. |
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