Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis
文献类型：期刊论文
| 作者 | Ji, LL; Wang, Z; Dong, F; Zhang, WB; Wang, ZT |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2005 |
| 卷号 | 95期号:5页码:970-978 |
| 关键词 | andrograpanin chemokine leukocyte SDF-1 alpha CXCR4 chemotaxis internalization |
| 通讯作者 | Wang, ZT (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,herbs@mailbox.cpu.edu.cn |
| 英文摘要 | Andrographis paniculata is a traditional Chinese medicine (TCM) that has been effectively used for treatment of infection, inflammation, cold, fever, and diarrhea in China. However, mechanism of its therapeutic function is not well known. In the current study, we showed one of its components, andrograpanin, could enhance chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) induced chemotaxis in Jurkat and THP-1 cells. Further study demonstrated that this kind of effect was CXC chemokine receptor-4 (CXCR4) specific, since andrograpanin could not enhance other chemokines, such as RANTES, monocyte chemotactic protein-1 (MCP-1), etc. induced cell chemotaxis. Mechanisms of andrograpanin exerting its effect were not directly in the receptor and G protein coupling level because it had no effect on the binding of SDF-1 to CXCR4, SDF-1 induced G protein activation and adenyly cyclase inhibition. However, receptor internalization might be involved, since we found it significantly reduced SDF-1 alpha-induced CXCR4 internalization. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | NITRIC-OXIDE SYNTHASE ; RECEPTOR CXCR4 ; TRANSENDOTHELIAL MIGRATION ; FUNCTIONAL EXPRESSION ; CELL CHEMOTAXIS ; ADHESION ; PROTEIN ; SUPPRESSION ; ACTIVATION ; INTERNALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230960900009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1911]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ji, LL,Wang, Z,Dong, F,et al. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2005,95(5):970-978. |
| APA | Ji, LL,Wang, Z,Dong, F,Zhang, WB,&Wang, ZT.(2005).Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis.JOURNAL OF CELLULAR BIOCHEMISTRY,95(5),970-978. |
| MLA | Ji, LL,et al."Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis".JOURNAL OF CELLULAR BIOCHEMISTRY 95.5(2005):970-978. |
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