Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits
文献类型：期刊论文
| 作者 | Wang, LM; Yan, Y; Zou, LJ; Jing, NH; Xu, ZY |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 15期号:5页码:387-393 |
| 关键词 | spinal cord ischemia apoptosis hypothermia |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Stem Cell Biol,Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn ; zhiyunxu@smmu.edu.cn |
| 英文摘要 | Paraplegia is a disastrous complication after operations of descending and thoracoabdominal aortic aneurysm. Regional hypothermia protects against spinal cord ischemia although the protective mechanism is not well know. The objective of this study is to examine whether hypothermia protects the spinal cord by preventing apoptosis of nerve cell and also investigate a possible mechanism involved in hypothermia neuroprotection. Cell apoptosis with necrosis was evident in the spinal cord 24 h after 30 min of ischemia. Moderate hypothermia decreased the incidence of apoptotic nerve cells. Both cell apoptosis and necrosis were attenuated by hypothermia. p53 expression increased and bcl-2 expression declined after ischemia, while hypothermia mitigated these changes. This study suggests that apoptosis contributes to cell death after spinal cord ischemia, and that moderate hypothermia can prevent nerve cell apoptosis by a mechanism associated with bcl-2 and p53 genes. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | THORACOABDOMINAL ANEURYSM REPAIR ; FOCAL CEREBRAL-ISCHEMIA ; MILD HYPOTHERMIA ; MOTOR-NEURONS ; RAT-BRAIN ; DEATH ; BCL-2 ; EXPRESSION ; PROTEIN ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230838800008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1919]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, LM,Yan, Y,Zou, LJ,et al. Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits[J]. CELL RESEARCH,2005,15(5):387-393. |
| APA | Wang, LM,Yan, Y,Zou, LJ,Jing, NH,&Xu, ZY.(2005).Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits.CELL RESEARCH,15(5),387-393. |
| MLA | Wang, LM,et al."Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits".CELL RESEARCH 15.5(2005):387-393. |
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