Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages
文献类型：期刊论文
| 作者 | Wang, Y; Chang, ZL |
| 刊名 | BIOLOGY OF THE CELL
 |
| 出版日期 | 2005 |
| 卷号 | 97期号:7页码:551-556 |
| 关键词 | heat-shock response interferon-gamma (IFN-gamma) interferon consensus-sequence binding protein (ICSBP) interleukin-18 (IL-18) macrophage |
| 通讯作者 | Wang, Y (reprint author), Third Mil Med Univ, SW Hosp, Inst Burn Res, Chongqing 400038, Peoples R China.,yunyunwy@hotmail.com |
| 英文摘要 | Background information. The heat-shock response is a self-defence mechanism that protects cells and organisms from a wide range of harmful stresses. Recent studies revealed that it involved the regulation of cytokine expression. Interleukin-18 (IL-18) is an important cytokine in mediating immune response. Results. We studied interferon-gamma (IFN-gamma)-induced IL-18 expression in heat-shock-treated murine peritoneal macrophages. Our results showed that the heat-shock response significantly inhibited the expression of IFN-gamma-induced pro-inflammatory cytokine IL-18. Interferon consensus sequence binding protein (ICSBP) is a transcription factor that binds to the promoter of IL-18 and regulates the transcription of IL-18. Further research on the down-regulation mechanism showed that the DNA-binding activity of ICSBP was greatly reduced by the heat shock response. Conclusions. These results suggest that the inhibitory effect of heat-shock response on IL-18 production in IFN-gamma-stimulated macrophages is related to the suppression of the binding activity of ICSBP. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | SEQUENCE-BINDING-PROTEIN ; IFN-GAMMA ; SIGNALING PATHWAY ; INTERFERON-GAMMA ; IL-18 ; STRESS ; CELLS ; P40 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000230780300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1933]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Y,Chang, ZL. Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages[J]. BIOLOGY OF THE CELL,2005,97(7):551-556. |
| APA | Wang, Y,&Chang, ZL.(2005).Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages.BIOLOGY OF THE CELL,97(7),551-556. |
| MLA | Wang, Y,et al."Heat-shock response down-regulates interleukin-18 expression in murine peritoneal macrophages".BIOLOGY OF THE CELL 97.7(2005):551-556. |
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