The modulation of apoptosis by cyclic,AMP involves Akt and epidermal growth factor receptor
文献类型：期刊论文
| 作者 | Zhou, B; Li, FQ; Chen, HH; Song, JG |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
 |
| 出版日期 | 2005 |
| 卷号 | 37期号:7页码:1483-1495 |
| 关键词 | apoptosis adenosine 3 ' epidermal growth factor receptor signaling transforming growth factor-beta 1 5 '-cyclic monophosphate |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 32 Yue Yang Rd, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | Adenosine 3',5'-cyclic monophosphate (cAMP) and transforming growth factor-P are important regulators of many biological processes. In this study we investigated the effect and its potential mechanism of cAMP on transforming growth factor-beta 1- and serum deprivation-induced apoptosis in Mv1Lu cells. Transforming growth factor-beta 1 treatment or serum deprivation induces apoptotic response in Mv1Lu cells. Forskolin, a cAMP-elevating agent, or 8-Bromo-cAMP (8-B-cAMP), a cell permeable cAMP analogue, inhibited the cell proliferation and markedly enhanced apoptosis induced by transforming growth factor-beta 1, but completely suppressed serum deprivation-induced apoptosis. Furthermore, forskolin decreased the Akt phosphorylation, and the inhibition of phosphafidylinositol-3 kinase by LY294002 sensitized Mv1Lu cells to transforming growth factor-beta 1-induced apoptosis. In addition, forskolin treatment induced tyrosine phosphorylation of epidermal growth factor receptor. Inhibition of epidermal growth factor receptor by specific inhibitor PD 153035 blocked the cAMP-mediated suppression of serum deprivation-induced apoptosis. The results indicate that cAMP exerts its opposite effects in transforming growth factor-beta 1- and serum deprivation-induced apoptosis via a mechanism involving the modulation of signaling components of phosphatidylinositol-3-kinase/Akt and epidermal growth factor receptor in Mv1Lu cells. (c) 2005 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | NECROSIS-FACTOR-ALPHA ; FAS-INDUCED APOPTOSIS ; TGF-BETA ; PROTEIN-KINASE ; CELL-SURVIVAL ; MAP KINASE ; EPITHELIAL-CELLS ; EGF RECEPTOR ; TYROSINE PHOSPHORYLATION ; SIGNAL-TRANSDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000229161600015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1936]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, B,Li, FQ,Chen, HH,et al. The modulation of apoptosis by cyclic,AMP involves Akt and epidermal growth factor receptor[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2005,37(7):1483-1495. |
| APA | Zhou, B,Li, FQ,Chen, HH,&Song, JG.(2005).The modulation of apoptosis by cyclic,AMP involves Akt and epidermal growth factor receptor.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,37(7),1483-1495. |
| MLA | Zhou, B,et al."The modulation of apoptosis by cyclic,AMP involves Akt and epidermal growth factor receptor".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 37.7(2005):1483-1495. |
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