Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor
文献类型：期刊论文
| 作者 | Okumura, K; Zhao, MJ; DePinho, RA; Furnari, FB; Cavenee, WK |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2005 |
| 卷号 | 102期号:8页码:2703-2706 |
| 通讯作者 | Cavenee, WK (reprint author), Univ Calif San Diego, Ludwig Inst Canc Res, San Diego Branch, La Jolla, CA 92093 USA.,wcavenee@ucsd.edu |
| 英文摘要 | The PTEN (phosphatase and tensin homologue) tumor suppressor protein contains a single catalytic domain with both lipid and protein phosphatase activities. The remaining C-terminal half of the PTEN protein plays a role in its stability and is mutated in many clinical cancer samples. Here, we report that the PTEN C-terminal domain physically interacts with the forkhead-associated domain of the oncogenic MSP58 protein and that this interaction requires PTEN Thr-366. We further show that while MSP58 transforms Pten-/- mouse embryo fibroblasts (MEFs), concurrent introduction of wild-type PTEN causes a dramatic reduction in the number of MSP58-induced transformed foci. This PTEN-mediated inhibition of cellular transformation requires physical interaction as evidenced by the failure of PTEN(T366A) point mutation (residing within the MSP58 interaction domain) to suppress MSP-58-driven transformation. These observations, together with the capacity of catalytically inactive PTEN mutant (G129R) to suppress MSP58 oncogenicity, support the view that the C-terminal region of PTEN directly provides a previously uncharacterized biological function in its ability to regulate cellular transformation. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | 58-KDA MICROSPHERULE PROTEIN ; FHA DOMAIN ; PHOSPHORYLATION ; PHOSPHATASES ; MIGRATION ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000227232400009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1947]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Okumura, K,Zhao, MJ,DePinho, RA,et al. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(8):2703-2706. |
| APA | Okumura, K,Zhao, MJ,DePinho, RA,Furnari, FB,&Cavenee, WK.(2005).Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(8),2703-2706. |
| MLA | Okumura, K,et al."Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.8(2005):2703-2706. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。