Hyaluronan promotes tumor lymphangiogenesis and intralymphantic tumor growth in xenografts
文献类型：期刊论文
| 作者 | Guo, LX; Zou, K; Ju, JH; Xie, H |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2005 |
| 卷号 | 37期号:9页码:601-606 |
| 关键词 | hyaluronan tumor lymphangiogenesis intralymphatic tumor growth |
| 通讯作者 | Xie, H (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Lab Biotherapy,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,hxie@sibs.ac.cn |
| 英文摘要 | Hyaluxonan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, has been implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mice, then angiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for platelet-endothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 respectively. Interestingly, we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphatic vessels, but has little effect on tumor angiogenesis. Moreover, HA also promotes intralymphatic tumor growth, although it is not sufficient to potentiate lymphatic metastasis. These results suggest that HA, which is elevated in most malignant tumor stroma, may also play a role in tumor progression by promoting lymphangiogenesis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | CANCER METASTASIS ; PROSTATE-CANCER ; CELL-MIGRATION ; BREAST-CANCER ; VEGF-D ; EXPRESSION ; RECEPTOR ; LYVE-1 ; ANGIOGENESIS ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000232014100004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1951]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Guo, LX,Zou, K,Ju, JH,et al. Hyaluronan promotes tumor lymphangiogenesis and intralymphantic tumor growth in xenografts[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2005,37(9):601-606. |
| APA | Guo, LX,Zou, K,Ju, JH,&Xie, H.(2005).Hyaluronan promotes tumor lymphangiogenesis and intralymphantic tumor growth in xenografts.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,37(9),601-606. |
| MLA | Guo, LX,et al."Hyaluronan promotes tumor lymphangiogenesis and intralymphantic tumor growth in xenografts".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 37.9(2005):601-606. |
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