p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells
文献类型：期刊论文
| 作者 | Jin, Y; Leung, WK; Sung, JJY; Wu, JR |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 15期号:9页码:695-703 |
| 关键词 | pRB degradation p53 apoptosis |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,wujr@sibs.ac.cn |
| 英文摘要 | The retinoblastoma (RB) tumor suppressor protein, pRB, plays an important role in the regulation of mammalian cell cycle. Furthermore, several lines of evidence suggest that pRB also involves in the regulation of apoptosis. In the present study, the degradation of pRB was observed in apoptotic gastric tumor cells treated with a new potent anti-tumor component, tripchlorolide (TC). The inhibition of pRB degradation by a general cysteine protease inhibitor IDAM resulted in the reduction of the apoptotic cells. Furthermore, the survival of the gastric tumor cells under the TC treatment was enhanced by an over-expression of exogenous pRB. These results suggest that the pRB degradation of the gastric tumor cells under the TC treatment involves in the apoptotic progression. In addition, the same extent of TC-induced pRB-degradation was detected in the gastric tumor cells containing a p53 dominant-negative construct, indicating that this kind of pRB degradation is p53-independent. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | UBIQUITIN-PROTEASOME PATHWAY ; TUMOR SUPPRESSORS RB ; RETINOBLASTOMA PROTEIN ; GENE-PRODUCT ; DIFFERENTIAL REGULATION ; MEDIATED APOPTOSIS ; FAMILY PROTEINS ; E7 ONCOPROTEIN ; DNA-DAMAGE ; CHO-CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000232349100003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1952]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jin, Y,Leung, WK,Sung, JJY,et al. p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells[J]. CELL RESEARCH,2005,15(9):695-703. |
| APA | Jin, Y,Leung, WK,Sung, JJY,&Wu, JR.(2005).p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells.CELL RESEARCH,15(9),695-703. |
| MLA | Jin, Y,et al."p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells".CELL RESEARCH 15.9(2005):695-703. |
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