Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta 1 and monocyte chemoattractant PROTEIN-1 expression in bleomycin-induced lung fibrosis in mice
文献类型：期刊论文
| 作者 | Shen, Y; Zhao, HL; Du, J; Li, YT; Tan, F; Huang, CG; Pei, G |
| 刊名 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
 |
| 出版日期 | 2005 |
| 卷号 | 32期号:12页码:1071-1077 |
| 关键词 | bleomycin Feitai lung fibrosis mice monocyte chemoattractant protein-1 transforming growth factor-beta 1 |
| 通讯作者 | Shen, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200231, Peoples R China.,shenyun@sibs.ac.cn |
| 英文摘要 | 1. Feitai, a Chinese medicine formulation, has been shown to protect against lung fibrosis induced by bleomycin (BLM). In the present study, we investigated the effect of Feitai on transforming growth factor (TGF)-beta 1 and monocyte chemoattractant protein-1 (MCP-1), which play important roles in the pathogenesis of BLM-induced lung fibrosis. 2. The results demonstrated that Feitai could significantly attenuate BLM-induced acute lung inflammation and subsequent lung fibrosis. Meanwhile, the expression of MCP-1 and TGF-beta(1), mRNA in the lungs increased in the BLM-treated group compared with the saline-instilled control group and Feitai treatment significantly decreased cytokine expression in BLM-treated mice. In addition, Feitai diminished the accumulation of MCP-1- and TGF-beta 1-positive cells in lung tissues at the time of peak mRNA levels. 3. In summary, the results of the present study indicate that treatment with Feitai ameliorates BLM-induced lung fibrosis, at least in part via the inhibition of MCP-1 and TGF-beta(1), expression. |
| 学科主题 | Pharmacology & Pharmacy; Physiology |
| 类目[WOS] | Pharmacology & Pharmacy ; Physiology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; INDUCED PULMONARY-FIBROSIS ; MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; FIBRONECTIN MESSENGER-RNAS ; HUMAN DERMAL FIBROBLASTS ; GENE-EXPRESSION ; CELL-PROLIFERATION ; GELATINASE B ; TGF-BETA ; COLLAGEN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234715900009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1968]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Shen, Y,Zhao, HL,Du, J,et al. Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta 1 and monocyte chemoattractant PROTEIN-1 expression in bleomycin-induced lung fibrosis in mice[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2005,32(12):1071-1077. |
| APA | Shen, Y.,Zhao, HL.,Du, J.,Li, YT.,Tan, F.,...&Pei, G.(2005).Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta 1 and monocyte chemoattractant PROTEIN-1 expression in bleomycin-induced lung fibrosis in mice.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,32(12),1071-1077. |
| MLA | Shen, Y,et al."Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta 1 and monocyte chemoattractant PROTEIN-1 expression in bleomycin-induced lung fibrosis in mice".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 32.12(2005):1071-1077. |
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