beta-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappa B activation
文献类型：期刊论文
| 作者 | Luan, B; Zhang, ZN; Wu, YL; Kang, JH; Pei, G |
| 刊名 | EMBO JOURNAL
 |
| 出版日期 | 2005 |
| 卷号 | 24期号:24页码:4237-4246 |
| 关键词 | beta-arrestin2 CK2 NF-kappa B |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | NF-kappa B activation is an important mechanism of mammalian UV response to protect cells. UV-induced NF-kappa B activation depends on the casein kinase II (CK2) phosphorylation of I kappa B alpha at a cluster of C-terminal sites, but how it is regulated remains unclear. Here we demonstrate that beta-arrestin2 can function as an effective suppressor of UV-induced NF-kappa B activation through its direct interaction with I kappa B alpha. CK2 phosphorylation of beta-arrestin2 blocks its interaction with I kappa B alpha and abolishes its suppression of NF-kappa B activation, indicating that the beta-arrestin2 phosphorylation is critical. Moreover, stimulation of beta(2)-adrenergic receptors, a representative of G-protein-coupled receptors in epidermal cells, promotes dephosphorylation of beta-arrestin2 and its suppression of NF-kappa B activation. Consequently, the beta-arrestin2 suppression leads to promotion of UV-induced cell death, which is also under regulation of beta-arrestin2 phosphorylation. Thus, beta-arrestin2 is identified as a phosphorylation-regulated suppressor of UV response and this may play a functional role in the response of epidermal cells to UV. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | CLATHRIN-MEDIATED ENDOCYTOSIS ; BETA-ARRESTINS ; BETA(2)-ADRENERGIC RECEPTOR ; ULTRAVIOLET-RADIATION ; ADRENERGIC-RECEPTOR ; HUMAN SKIN ; APOPTOSIS ; UBIQUITINATION ; DEGRADATION ; EPIDERMIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234805100003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1987]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Luan, B,Zhang, ZN,Wu, YL,et al. beta-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappa B activation[J]. EMBO JOURNAL,2005,24(24):4237-4246. |
| APA | Luan, B,Zhang, ZN,Wu, YL,Kang, JH,&Pei, G.(2005).beta-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappa B activation.EMBO JOURNAL,24(24),4237-4246. |
| MLA | Luan, B,et al."beta-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappa B activation".EMBO JOURNAL 24.24(2005):4237-4246. |
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