Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion
文献类型：期刊论文
| 作者 | Yang, YJ; Shen, Y; Chen, SH; Ge, XR |
| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| 出版日期 | 2005 |
| 卷号 | 11期号:29页码:4524-4529 |
| 关键词 | IL-18 Ischemia Reperfusion Inflammation |
| 通讯作者 | Ge, XR (reprint author), Chinese Acad Sci, Cell Resources Ctr, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,gexirui@sibs.ac.cn |
| 英文摘要 | AIM: To study the changes of endogenous interleukin 18 (IL-18) levels and evaluate the role of IL-18 on lung injury following gut ischemia/reperfusion. METHODS: A superior mesenteric artery occlusion model was selected for this research. The mice were randomly divided into four groups: Sham operation (sham), ischemia (0.5 h) followed by different times of reperfusion (I/R), and I/R pretreated with exogenous IL-18 (I/R+IL-18) or IL-18 neutralizing antibody (I/R+IL-18Ab) 15 min before ischemia. Serum IL-18 levels were detected by Western blot and ELISA, and the levels of IL-18 in lung tissue were evaluated by immunohistochemical staining. For the study of pulmonary inflammation, the lung myeloperoxidase (MPO) contents and morphological changes were evaluated. RESULTS: Gut ischemia/reperfusion induced rapid increase of serum IL-18 levels, peaked at 1 h after reperfusion and then declined. The levels of IL-18 in lung tissue were gradually enhanced as the progress of reperfusion. Compared with I/R group, exogenous administration of IL-18 (I/R+IL-18) further remarkably enhanced the pulmonary MPO activity and inflammatory cell infiltration, and in I/R+IL-18Ab group, the content of MPO were significantly reduced and lung inflammation was also decreased. CONCLUSION: Gut ischemia/reperfusion induces the increase of IL-18 expression, which may make IL-18 act as an important proinflammatory cytokine and contribute to gut ischemia/reperfusion-induced lung inflammation. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved. |
| 学科主题 | Gastroenterology & Hepatology |
| 类目[WOS] | Gastroenterology & Hepatology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000208099400013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1990]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, YJ,Shen, Y,Chen, SH,et al. Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(29):4524-4529. |
| APA | Yang, YJ,Shen, Y,Chen, SH,&Ge, XR.(2005).Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion.WORLD JOURNAL OF GASTROENTEROLOGY,11(29),4524-4529. |
| MLA | Yang, YJ,et al."Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion".WORLD JOURNAL OF GASTROENTEROLOGY 11.29(2005):4524-4529. |
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