beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells
文献类型：期刊论文
| 作者 | Pan, WJ; Jia, YY; Wang, JY; Tao, DL; Gan, XQ; Tsiokas, L; Jing, NH; Wu, DQ; Li, L |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2005 |
| 卷号 | 102期号:48页码:17378-17383 |
| 关键词 | Wnt |
| 通讯作者 | Li, L (reprint author), Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA.,dwu@neuron.uchc.edu ; lli@sibs.ac.cn |
| 英文摘要 | Wnt/beta-catenin signaling plays a critical role in embryonic myogenesis. Here we show that, in P19 embryonic carcinoma stem cells, Wnt/beta-catenin signaling initiates the myogenic process depends on beta-catenin-mediated relief of 1-mfa (inhibitor of MyoD Family a) suppression of myogenic regulatory factors (MRFs). We found that beta-catenin interacted with 1-mfa and that the interaction was enhanced by Wnt3a. In addition, we found that the interaction between beta-catenin and 1-mfa was able to attenuate the interaction of 1-mfa with MRFs, relieve 1-mfa-mediated suppression of the transcriptional activity and cytosolic sequestration of MRFs, and initiate myogenesis in a P1 9 myogenic model system that expresses exogenous myogenin. This work reveals a mechanism for the regulation of MRFs during myogenesis by elucidating beta-catenin-mediated, but lymphoid enhancing factor-1/T cell factor independent, mechanism in regulation of myogenic fate specification and differentiation of P19 mouse stem cells. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | WNT SIGNALING PATHWAY ; SKELETAL MYOGENESIS ; TRANSCRIPTION FACTORS ; MYOD FAMILY ; DEP DOMAIN ; ACTIVATION ; EXPRESSION ; GENE ; SPECIFICATION ; SOMITE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000233762000022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1993]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Pan, WJ,Jia, YY,Wang, JY,et al. beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(48):17378-17383. |
| APA | Pan, WJ.,Jia, YY.,Wang, JY.,Tao, DL.,Gan, XQ.,...&Li, L.(2005).beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(48),17378-17383. |
| MLA | Pan, WJ,et al."beta-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.48(2005):17378-17383. |
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