Tau alternative splicing and frontotemporal dementia
文献类型：期刊论文
| 作者 | Kar, A; Kuo, D; He, RQ; Zhou, JW; Wu, JY |
| 刊名 | ALZHEIMER DISEASE & ASSOCIATED DISORDERS
 |
| 出版日期 | 2005 |
| 卷号 | 19期号:1页码:S29-S36 |
| 关键词 | frontotemporal dementia tau alternative splicing |
| 通讯作者 | Wu, JY (reprint author), Vanderbilt Univ, Med Ctr, Dept Pharmacol,Dept Pediat, Dept Cell & Dev Biol,John F Kennedy Ctr Res Human, Nashville, TN 37232 USA.,jane.wu@vanderbilt.edu |
| 英文摘要 | A number of neurodegenerative diseases are characterized by the presence of abundant deposits containing Tau protein. Expression of the human tau gene is under complex regulation. Mutations in the tau gene have been identified in patients with frontotemporal lobe dementia. These mutations affect either biochemical/biophysical properties or the delicate balance of different splicing isoforms. In this review, we summarize recent advances in our understanding of genetics and molecular pathogenesis of tauopathies with the focus on frontotemporal lobe dementia. We review published studies on tau pre-mRNA splicing regulation. Understanding molecular mechanisms of tauopathies may help in developing effective therapies for neurodegenerative tauopathies and related disorders, including Alzheimer disease. |
| 学科主题 | Neurosciences & Neurology; Pathology |
| 类目[WOS] | Clinical Neurology ; Pathology |
| 关键词[WOS] | PROGRESSIVE SUPRANUCLEAR PALSY ; MULTIPLE SYSTEM TAUOPATHY ; PRE-MESSENGER-RNA ; EXON 10 ; PROTEIN-TAU ; TRANSGENIC MICE ; GENE MUTATION ; MICROTUBULE-BINDING ; PRESENILE-DEMENTIA ; AXONAL-TRANSPORT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234136300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1998]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Kar, A,Kuo, D,He, RQ,et al. Tau alternative splicing and frontotemporal dementia[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS,2005,19(1):S29-S36. |
| APA | Kar, A,Kuo, D,He, RQ,Zhou, JW,&Wu, JY.(2005).Tau alternative splicing and frontotemporal dementia.ALZHEIMER DISEASE & ASSOCIATED DISORDERS,19(1),S29-S36. |
| MLA | Kar, A,et al."Tau alternative splicing and frontotemporal dementia".ALZHEIMER DISEASE & ASSOCIATED DISORDERS 19.1(2005):S29-S36. |
入库方式： OAI收割
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