The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination
文献类型：期刊论文
| 作者 | Yang, K; Zhu, JM; Sun, SG; Tang, YJ; Zhang, BH; Diao, LR; Wang, C |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004 |
| 卷号 | 324期号:1页码:432-439 |
| 关键词 | TRAF6 coiled-coil domain nuclear factor-KB ubiquitin |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn |
| 英文摘要 | Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial signaling transducer that regulates a diverse array of physiological processes, including adaptive immunity, innate immunity, and bone metabolism. Importantly, it is essential for activating NF-kappaB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. Previously, we characterized TRAF6 to be a ubiquitin ligase. In combination with the ubiquitin conjugating enzyme complex Ubc13/Uev1A, TRAF6 could catalyze the formation on itself of unique Lys-63 linked polyubiquitin chain that positively regulated NF-kappaB signaling pathway. However, it remains unknown how this auto-ubiquitination process is regulated. In this study, we found that the coiled-coil domain of TRAF6 was essential for its auto-ubiquitination and activating NF-kappaB signaling pathway. This domain served not as the specific target where the polyubiquitin chain was linked, but as a specific bridge to recruit Ubc13/Uev1A. (C) 2004 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | NECROSIS-FACTOR RECEPTOR ; I-KAPPA-B ; INTERLEUKIN-1 ; PROTEIN ; KINASE ; ACTIVATION ; IL-1 ; TAK1 ; UBIQUITINATION ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224595300065 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2006]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, K,Zhu, JM,Sun, SG,et al. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,324(1):432-439. |
| APA | Yang, K.,Zhu, JM.,Sun, SG.,Tang, YJ.,Zhang, BH.,...&Wang, C.(2004).The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,324(1),432-439. |
| MLA | Yang, K,et al."The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324.1(2004):432-439. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。