Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients
文献类型：期刊论文
| 作者 | Zeng, R; Yang, RF; Shi, MD; Jiang, MR; Xie, YH; Ruan, HQ; Jiang, XS; Shi, L; Zhou, H; Zhang, L |
| 刊名 | JOURNAL OF MOLECULAR BIOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 341期号:1页码:271-279 |
| 关键词 | SARS coronavirus 3a protein spike protein proteome |
| 通讯作者 | Zeng, R (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Res Ctr Proteome Anal, Key Lab Proteon, 320 Yue-Yang Rd, Shanghai 200031, Peoples R China.,zr@sibs.ac.cn ; bingsun@sibs.ac.cn ; wujr@sibs.ac.cn |
| 英文摘要 | Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment. (C) 2004 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TRANSMISSIBLE GASTROENTERITIS VIRUS ; PORCINE RESPIRATORY CORONAVIRUS ; SPIKE PROTEIN ; MEMBRANE-FUSION ; SEQUENCE ; GENOME ; IDENTIFICATION ; REVEALS ; ORF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000222925100022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2009]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zeng, R,Yang, RF,Shi, MD,et al. Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients[J]. JOURNAL OF MOLECULAR BIOLOGY,2004,341(1):271-279. |
| APA | Zeng, R.,Yang, RF.,Shi, MD.,Jiang, MR.,Xie, YH.,...&Wu, JR.(2004).Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients.JOURNAL OF MOLECULAR BIOLOGY,341(1),271-279. |
| MLA | Zeng, R,et al."Characterization of the 3a protein of SARS-associated coronavirus in infected Vero e6 cells and SARS patients".JOURNAL OF MOLECULAR BIOLOGY 341.1(2004):271-279. |
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