Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates
文献类型：期刊论文
| 作者 | Yan, Y; Bian, W; Xie, ZQ; Cao, XM; Le Roux, I; Guillemot, F; Jing, NH |
| 刊名 | DEVELOPMENTAL DYNAMICS
 |
| 出版日期 | 2004 |
| 卷号 | 231期号:2页码:248-257 |
| 关键词 | Stat3 pYStat3 central nervous system eye development in ovo electroporation mouse chick |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn |
| 英文摘要 | Stat3, a member of the signal transducer and activator of transcription (STAT) family, plays a central role in mediating cell growth, differentiation, and survival signals. In this report, we show that Stat3 immunoreactivity was localized to specific regions in the developing mouse brain, neural tube, and eye from embryonic day 10.5 to postnatal day 0. The active form of Stat3 protein, which is phosphorylated on tyrosine 705 (pYStat3), was also found in the developing neural tube with more restricted distribution. An in ovo chick embryo electroporation assay showed that the endogenous chick Stat3 could drive consensus sis-inducible element-directed reporter gene expression. These results demonstrate that the active Stat3 protein is present and might play a role during the development of the central nervous system and eye. (C) 2004 Wiley-Liss, Inc. |
| 学科主题 | Anatomy & Morphology; Developmental Biology |
| 类目[WOS] | Anatomy & Morphology ; Developmental Biology |
| 关键词[WOS] | LEUKEMIA INHIBITORY FACTOR ; SPINAL-CORD PRECURSORS ; FACTOR-RECEPTOR ; ASTROCYTE DIFFERENTIATION ; TARGETED DISRUPTION ; NEUROTROPHIC FACTOR ; NEURITE OUTGROWTH ; MOTOR-NEURONS ; GENE ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223883700002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2031]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yan, Y,Bian, W,Xie, ZQ,et al. Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates[J]. DEVELOPMENTAL DYNAMICS,2004,231(2):248-257. |
| APA | Yan, Y.,Bian, W.,Xie, ZQ.,Cao, XM.,Le Roux, I.,...&Jing, NH.(2004).Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates.DEVELOPMENTAL DYNAMICS,231(2),248-257. |
| MLA | Yan, Y,et al."Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates".DEVELOPMENTAL DYNAMICS 231.2(2004):248-257. |
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