Design and synthesis of glyco-replica tripeptides based on molecular modeling
文献类型：期刊论文
| 作者 | Shan, L; Xu, JC; Xia, ZX; Li, JD; Wang, KY |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2004 |
| 卷号 | 62期号:2页码:199-203 |
| 关键词 | glucoamylase glyco-replica peptide molecular modeling liquid phase synthesis |
| 通讯作者 | Shan, L (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China.,xiazx@mail.sioc.ac.cn |
| 英文摘要 | Based on the results of phage display, the interactions between three glyco-replica peptides and glucoamylase were investigated by molecular dynamics simulation. The results of the computer modeling showed that the basic amino acid residue at N-terminus of each oligopeptide was bound to the active sites of the enzyme. Three tripeptides were designed using molecular modeling and synthesized by liquid phase synthesis method, which are to be used to prepare the crystals of the complexes with glucoamylase or alpha-amylase. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 关键词[WOS] | AWAMORI VAR X100 ; 2.4-ANGSTROM RESOLUTION ; REFINED STRUCTURE ; PEPTIDE LIBRARY ; GLUCOAMYLASE ; INHIBITOR ; ACARBOSE ; COMPLEX |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000188418600017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2046]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Shan, L,Xu, JC,Xia, ZX,et al. Design and synthesis of glyco-replica tripeptides based on molecular modeling[J]. ACTA CHIMICA SINICA,2004,62(2):199-203. |
| APA | Shan, L,Xu, JC,Xia, ZX,Li, JD,&Wang, KY.(2004).Design and synthesis of glyco-replica tripeptides based on molecular modeling.ACTA CHIMICA SINICA,62(2),199-203. |
| MLA | Shan, L,et al."Design and synthesis of glyco-replica tripeptides based on molecular modeling".ACTA CHIMICA SINICA 62.2(2004):199-203. |
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