A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent
文献类型：期刊论文
| 作者 | Zou, WG; Luo, CX; Zhang, ZL; Liu, J; Gu, JF; Pei, ZF; Qian, C; Liu, XY |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2004 |
| 卷号 | 23期号:2页码:457-464 |
| 关键词 | oncolytic adenovirus E1A gene hTERT promoter telomerase cancer |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Telomerase is a therapeutic target for cancer. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of the telomerase, is transcriptionaly upregulated exclusively in about 90#37; of cancer cells. Previous studies have demonstrated that hTERT promoter can control the expression of exogenous genes to the telomerase-positive cancer cells, thus hTERT promoter is an excellent candidate for generating cancer-specific oncolytic adenovirus. In this study, we devised a novel oncolytic adenovirus (Ad.TERT) by replacing the normal E1A regulatory elements with hTERT promoter. Ad.TERT displays cancer-specific E1A expression, virus replication and cytolysis in in vitro experiments. In animal experiments, intratumoral administration of Ad.TERT demonstrates potent antitumoral efficacy at least in two xenograft models (Bcap37 and BEL7404). Ad.TERT was targeted by the telomerase activity in cancer cells and has potent antitumoral efficacy in vivo, and since telomerase activity is a wide-ranged tumor marker, Ad.TERT could be a powerful therapeutic agent for a variety of cancers. |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 关键词[WOS] | REPLICATION-COMPETENT ADENOVIRUS ; SUICIDE GENE-THERAPY ; EXPRESSING BACTERIAL NITROREDUCTASE ; REVERSE-TRANSCRIPTASE PROMOTER ; CATALYTIC SUBUNIT HTERT ; HUMAN CANCER-CELLS ; HUMAN BONE-MARROW ; PROSTATE-CANCER ; HEPATOCELLULAR-CARCINOMA ; BAX GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000188098300016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2047]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zou, WG,Luo, CX,Zhang, ZL,et al. A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent[J]. ONCOGENE,2004,23(2):457-464. |
| APA | Zou, WG.,Luo, CX.,Zhang, ZL.,Liu, J.,Gu, JF.,...&Liu, XY.(2004).A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent.ONCOGENE,23(2),457-464. |
| MLA | Zou, WG,et al."A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent".ONCOGENE 23.2(2004):457-464. |
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