Expression of an antimicrobial peptide identified in the male reproductive system of rats
文献类型：期刊论文
| 作者 | Sun, XJ; Wang, DN; Zhang, WJ; Wu, XF |
| 刊名 | MOLECULAR BIOTECHNOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 28期号:3页码:185-189 |
| 关键词 | beta-defensins bactericidal activity myristoylated Gly amino terminus tandem repeats |
| 通讯作者 | Wu, XF (reprint author), Shanghai Jiao Tong Univ, Coll Agr & Technol, Shanghai 200030, Peoples R China.,xfwu@sunm.shcnc.ac.cn |
| 英文摘要 | Bin1b is a beta-defensins-like molecule originally isolated from the rat epididymis. Owing to its bactericidal activity, Bin1b may have therapeutic properties suitable for the treatment of sexually transmitted diseases. The amino terminus of the mature Bin1b peptide contains a conserved myristoylated Gly residue. We studied the requirement of the terminal myristoylated Gly residue in the bactericidal activity of Bin1b and found that the terminal myristoylated Gly residue is not essential for the bactericidal activity. In addition, we expressed the tandem repeats of Bin1b in Escherichia coli and found that two tandem rep-eats of Bin1b protein were successfully expressed. The bacterially expressed tandem Bin1b repeats may be used in a diverse array of biochemical and cell biological studies. |
| 学科主题 | Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 关键词[WOS] | ESCHERICHIA-COLI ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225497000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2050]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, XJ,Wang, DN,Zhang, WJ,et al. Expression of an antimicrobial peptide identified in the male reproductive system of rats[J]. MOLECULAR BIOTECHNOLOGY,2004,28(3):185-189. |
| APA | Sun, XJ,Wang, DN,Zhang, WJ,&Wu, XF.(2004).Expression of an antimicrobial peptide identified in the male reproductive system of rats.MOLECULAR BIOTECHNOLOGY,28(3),185-189. |
| MLA | Sun, XJ,et al."Expression of an antimicrobial peptide identified in the male reproductive system of rats".MOLECULAR BIOTECHNOLOGY 28.3(2004):185-189. |
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