Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
文献类型：期刊论文
| 作者 | Song, H; Li, YL; Chen, GY; Xing, Z; Zhao, J; Yokoyama, KK; Li, TP; Zhao, MJ |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004 |
| 卷号 | 316期号:4页码:1116-1123 |
| 关键词 | nucleolar protein telomerase inhibitor cell-cycle regulation yeast two-hybrid screening cDNA |
| 通讯作者 | Zhao, MJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,mjzhao@sibs.ac.cn |
| 英文摘要 | Human LPTS/PinX1 is a telomerase-inhibitory protein, which binds to the telomere protein Pin2/TRF1 and the catalytic subunit hTERT of telomerase. To explore the proteins that might be involved in the telomerase pathway, we performed a yeast two-hybrid screening with LPTS/PinX1 as the bait. A novel gene, MCRS2, encoding for an isoform of MCRS1/p78 and MSP58 was isolated. The expression of MCRS2 protein is cell-cycle dependent, accumulating in the very early S phase. MCRS2 interacts with LPTS/PinX1 in vitro, in vivo and colocalizes with LPTS/PinX1 in cells. MCRS2 and its amino terminus inhibit telomerase activity in vitro and long-term overexpression of MCRS2 in SMMC-7721 cells results in a gradual and progressive shortening of telomeres. Our findings suggest that MCRS2 might be a linker between telomere maintenance and cell-cycle regulation. (C) 2004 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | 58-KDA MICROSPHERULE PROTEIN ; PUTATIVE-TUMOR-SUPPRESSOR ; FHA DOMAIN ; HEPATOCELLULAR-CARCINOMA ; TRF1 ; IDENTIFICATION ; CHROMOSOMES ; INTERACTS ; CANCER ; CRISIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000220579300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2074]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Song, H,Li, YL,Chen, GY,et al. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,316(4):1116-1123. |
| APA | Song, H.,Li, YL.,Chen, GY.,Xing, Z.,Zhao, J.,...&Zhao, MJ.(2004).Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,316(4),1116-1123. |
| MLA | Song, H,et al."Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 316.4(2004):1116-1123. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。