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Macromolecular network and new function of aminoacyl-tRNA synthetases

文献类型：期刊论文

作者Jia, J; Jin, YX
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2004
卷号31期号:4页码:291-295
关键词aminoacyl-tRNA synthetase macromolecular network multi-ARS complex
通讯作者Jin, YX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,yxjin@sunm.shcnc.ac.cn
英文摘要Aminoacyl-tRNA synthetases (ARS) are the oldest enzymes in the evolution. The amino acids are transferred to the cognate tRNAs by the aminoacyl-tRNA synthetases, and then involved in the synthesis of the protein. This process is very important to keep the stability and variety of the lives. With the coming of the post-genome research, one of the main objectives becomes to illustrate the structures and the function of the aminoacyl-tRNA synthetases. Based on the data from the structure biology and the bioimformatics, the multi-ARS complex seemed to be the main form in the eukaryote. In addition, mammalian ARSs consist of a sophisticated macromolecular network with the auxiliary proteins or the elongation factors. The recent discoveries show that aminoacyl-tRNA synthetases not only are the most important enzymes to the synthesis of the protein, but also are involved in the diverse cellular processes, such as regulation on the transcription and translation level, RNA splicing and trafficking, apoptosis, angiogenesis and inflammation.
学科主题Biochemistry & Molecular Biology; Biophysics
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]PROTEIN ; COMPLEX ; TRANSCRIPTION
收录类别SCI
语种中文
WOS记录号WOS:000222848800001
版本出版稿
源URL[http://202.127.25.143/handle/331003/2081]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714		 Jia, J,Jin, YX. Macromolecular network and new function of aminoacyl-tRNA synthetases[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2004,31(4):291-295.
APA Jia, J,&Jin, YX.(2004).Macromolecular network and new function of aminoacyl-tRNA synthetases.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,31(4),291-295.
MLA Jia, J,et al."Macromolecular network and new function of aminoacyl-tRNA synthetases".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31.4(2004):291-295.

入库方式： OAI收割

来源：上海生物化学与细胞生物学研究所

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