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An epididymis-specific beta-defensin is important for the initiation of sperm maturation
文献类型：期刊论文
| 作者 | Zhou, CX; Zhang, YL; Xiao, LQ; Zheng, M; Leung, KM; Chan, MY; Lo, PS; Tsang, LL; Wong, HY; Ho, LS |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 6期号:5页码:458-464 |
| 通讯作者 | Chan, HC (reprint author), Chinese Univ Hong Kong, Fac Med, Dept Physiol, Epithelial Cell Biol Res Ctr, Hong Kong, Hong Kong, Peoples R China.,hsiaocchan@cuhk.edu.hk |
| 英文摘要 | Although the role of the epididymis, a male accessory sex organ, in sperm maturation has been established for nearly four decades(1), the maturation process itself has not been linked to a specific molecule of epididymal origin. Here we show that Bin1b, a rat epididymis-specific beta-defensin with antimicrobial activity(2), can bind to the sperm head in different regions of the epididymis with varied binding patterns. In addition, Bin1b-expressing cells, either of epididymal origin or from a Bin1b-transfected cell line, can induce progressive sperm motility in immotile immature sperm. This induction of motility is mediated by the Bin1b-induced uptake of Ca2+, a mechanism that has a less prominent role in maintaining motility in mature sperm. In vivo antisense experiments show that suppressed expression of Bin1b results in reduced binding of Bin1b to caput sperm and in considerable attenuation of sperm motility and progressive movement. Thus, beta-defensin is important for the acquisition of sperm motility and the initiation of sperm maturation. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | RAT SPERMATOZOA ; ANTIMICROBIAL PEPTIDE ; CALCIUM-UPTAKE ; MOTILITY ; PROTEINS ; CAPACITATION ; INVOLVEMENT ; SECRETION ; HAMSTER ; HUMANS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000221432600018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2092]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, CX,Zhang, YL,Xiao, LQ,et al. An epididymis-specific beta-defensin is important for the initiation of sperm maturation[J]. NATURE CELL BIOLOGY,2004,6(5):458-464. |
| APA | Zhou, CX.,Zhang, YL.,Xiao, LQ.,Zheng, M.,Leung, KM.,...&Chan, HC.(2004).An epididymis-specific beta-defensin is important for the initiation of sperm maturation.NATURE CELL BIOLOGY,6(5),458-464. |
| MLA | Zhou, CX,et al."An epididymis-specific beta-defensin is important for the initiation of sperm maturation".NATURE CELL BIOLOGY 6.5(2004):458-464. |
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