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Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
文献类型：期刊论文
| 作者 | Xia, YF; Ye, BQ; Li, YD; Wang, JG; He, XJ; Lin, XF; Yao, XS; Ma, DW; Slungaard, A; Hebbel, RP |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 173期号:6页码:4207-4217 |
| 通讯作者 | Geng, JG (reprint author), Univ Minnesota, Sch Med, Vasc Biol Ctr, MMC 480,14-152 Phillips Wangensteen Bldg,420 Dela, Minneapolis, MN 55455 USA.,gengx011@umn.edu |
| 英文摘要 | NF-kappaB is a central transcriptional factor and a pleiotropic regulator of many genes involved in immunological responses. During the screening of a plant extract library of traditional Chinese herbal medicines, we found that NF-kappaB activity was potently inhibited by andrographolide (Andro), an abundant component of the plant Andrographis that has been commonly used as a folk remedy for alleviation of inflammatory disorders in Asia for millennia. Mechanistically, it formed a covalent adduct with reduced cysteine (62) of p50, thus blocking the binding of NF-kappaB oligonucleotide to nuclear proteins. Andro suppressed the activation of NF-kappaB in stimulated endothelial cells, which reduced the expression of cell adhesion molecule E-selectin and prevented E-selectin-mediated leukocyte adhesion under flow. It also abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo. Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | IN-VITRO ; PLASMA-CELLS ; PANICULATA ; ADHESION ; ROLES ; DNA ; BINDING ; VIVO ; PERITONITIS ; SUPPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223878000073 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2094]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xia, YF,Ye, BQ,Li, YD,et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50[J]. JOURNAL OF IMMUNOLOGY,2004,173(6):4207-4217. |
| APA | Xia, YF.,Ye, BQ.,Li, YD.,Wang, JG.,He, XJ.,...&Geng, JG.(2004).Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.JOURNAL OF IMMUNOLOGY,173(6),4207-4217. |
| MLA | Xia, YF,et al."Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50".JOURNAL OF IMMUNOLOGY 173.6(2004):4207-4217. |
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