Riboswitches: a novel gene regulatory element and a potential class of drug targets
文献类型：期刊论文
| 作者 | Luo, YF; Chen, YL |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2004 |
| 卷号 | 31期号:8页码:684-687 |
| 关键词 | riboswitch allosteric rearrangement gene regulation fundamental metabolic pathway |
| 通讯作者 | Chen, YL (reprint author), Zhejiang Univ, Coll Life Sci, Hangzhou 310029, Peoples R China.,yuelion@163.com |
| 英文摘要 | Riboswitches are metabolite-binding RNA structures that serve as a novel gene regulatory element for mRNAs. Located in certain mRNAs, they can directly bind relevant small metabolites but not protein factors, and subsequently allosteric rearrangements modulate associated mRNA activities. They are believed to regulate in a wide set of fundamental metabolic pathways including vitamin B-12 and methionine biosynthesis in bacteria. The recent discovery of natural riboswitches, especially its property that precisely controlling basic metabolic pathways via binding to certain ligands with high affinity and specificity, inspires scientists to notice its potential application in medical research. The progress on the riboswitches, its characteristics, the function mechanism as well as the thinking and research trend triggered by its finding were introduced. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | MESSENGER-RNA STRUCTURE ; EXPRESSION ; BACTERIA ; TRANSCRIPTION ; MECHANISM ; METABOLISM |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000223647600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2118]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Luo, YF,Chen, YL. Riboswitches: a novel gene regulatory element and a potential class of drug targets[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2004,31(8):684-687. |
| APA | Luo, YF,&Chen, YL.(2004).Riboswitches: a novel gene regulatory element and a potential class of drug targets.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,31(8),684-687. |
| MLA | Luo, YF,et al."Riboswitches: a novel gene regulatory element and a potential class of drug targets".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31.8(2004):684-687. |
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