Screening of inhibitory peptides of human natural antibodies from phage displayed library
文献类型：期刊论文
| 作者 | Zhang, X; Zhang, JB; Xu, LH; Yan, SK; Wang, KY |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2004 |
| 卷号 | 31期号:8页码:712-715 |
| 关键词 | phage display GS-I-B-4 Gal-alpha 1 hyperacute rejection human natural antibodies 3-Gal |
| 通讯作者 | Zhang, JB (reprint author), Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310006, Peoples R China.,jzhan2k@cram.zju.edu.cn |
| 英文摘要 | The initial barrier to the transplantation of pig organs to human is hyperacute rejection (HAR). HAR was initiated by the conjugation of human natural antibodies (XNA) with the Gal-alpha1,3-Gal which is thought to be the major xenoantigenic epitope present on pig tissues. Removal of antibodies directly against that structure may be critical to the success of pig to human xenotransplantation. The lectin GS-I-B-4 was used to screen phage-displayed peptide library XCX15 and identified a peptide mimetic of Gal-alpha1,3-Gal. A phage bearing the peptide SCTALSFPSFAFLARGT has been identified to bind human natural antibody strongly. This binding reaction can be competitively inhibited by melibiose. The peptide can also inhibit the human natural antibody-mediated agglutination of pig RBCs. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000223647600008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2119]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, X,Zhang, JB,Xu, LH,et al. Screening of inhibitory peptides of human natural antibodies from phage displayed library[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2004,31(8):712-715. |
| APA | Zhang, X,Zhang, JB,Xu, LH,Yan, SK,&Wang, KY.(2004).Screening of inhibitory peptides of human natural antibodies from phage displayed library.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,31(8),712-715. |
| MLA | Zhang, X,et al."Screening of inhibitory peptides of human natural antibodies from phage displayed library".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31.8(2004):712-715. |
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