Association between alcohol, smoking and HLA-DQA1*0201 genotype in psoriasis
文献类型：期刊论文
| 作者 | Zheng, GY; Wei, SC; Shi, TL; Li, YX |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2004 |
| 卷号 | 36期号:9页码:597-602 |
| 关键词 | psoriasis HLA-DQA1*0201 allele smoking alcohol association |
| 通讯作者 | Li, YX (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Bioinformat Ctr, Shanghai 200031, Peoples R China.,yxli@sibs.ac.cn |
| 英文摘要 | Psoriasis is a chronic skin disease triggered by genetic, environment or other risk factors such as infection, drugs, stress, moisture, alcohol, and smoking. A major psoriasis susceptibility locus at 6p21.3 has been identified. Further studies found that HLA-DQA1 *0201 allele was associated with psoriasis. However, there were few data exploring an association between the environmental factors and susceptibility genes. In this study, the samples of 189 patients with psoriasis and 333 healthy controls were collected with their consent and were carried on analysis through polymerase chain reaction sequence-specific primer (PCR-SSP). method. The proportion of male psoriasis patients engaging in the smoking and alcohol was much higher than that of the control group (P<0.005). The HLA-DQA1*0201 allele was present at significantly higher frequency in the patients with psoriasis (OR=4.25, P < 1.0 x 10(-6)). Association was found between smoking, alcohol and HLA-DQA1 *0201 in male patients with psoriasis (OR > 6.91, P <1.0 x 10(-4)). |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | GENOME-WIDE SCAN ; SUSCEPTIBILITY LOCUS ; PROTEIN-KINASE ; CHROMOSOME 6P ; CHINESE HAN ; CELL-LINE ; KERATINOCYTES ; VULGARIS ; HACAT ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223987100003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2125]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, GY,Wei, SC,Shi, TL,et al. Association between alcohol, smoking and HLA-DQA1*0201 genotype in psoriasis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2004,36(9):597-602. |
| APA | Zheng, GY,Wei, SC,Shi, TL,&Li, YX.(2004).Association between alcohol, smoking and HLA-DQA1*0201 genotype in psoriasis.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,36(9),597-602. |
| MLA | Zheng, GY,et al."Association between alcohol, smoking and HLA-DQA1*0201 genotype in psoriasis".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 36.9(2004):597-602. |
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